TLR4 signaling protects from excessive muscular damage induced by Bothrops jararacussu snake venom

被引：12

作者：

Paiva-Oliveira, Eustaquio Luiz ^{[1
]}

da Silva, Rafael Ferreira ^{[2
]}

Correa Leite, Paulo Emilio ^{[2
]}

Cogo, Jose Carlos ^{[3
]}

Quirico-Santos, Thereza ^{[2
]}

Lagrota-Candido, Jussara ^{[1
]}

机构：

[1] Univ Fed Fluminense, Inst Biol, Dept Immunobiol, BR-24020741 Niteroi, RJ, Brazil

[2] Univ Fed Fluminense, Inst Biol, Dept Cellular & Mol Biol, BR-24020741 Niteroi, RJ, Brazil

[3] Vale Paraiba Univ, Inst Res & Dev, Lab Physiol & Pharmacol, Sao Jose Dos Campos, Brazil

来源：

TOXICON | 2012年 / 60卷 / 08期

关键词：

Bothrops jararacussu; Toll-like; 4; receptor; Skeletal muscle; Snake venom; Inflammation; LEVEL LASER THERAPY; TOLL-LIKE RECEPTORS; SKELETAL-MUSCLE; MATRIX METALLOPROTEINASES; INFLAMMATORY RESPONSE; REGENERATION; MICE; EXPRESSION; LIGANDS; INJURY;

D O I：

10.1016/j.toxicon.2012.10.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Immune cells and skeletal muscle express Toll-like receptors (TLRs) that participate as sensors of tissue injury triggering signals for activation of innate and adaptive immune responses. This study aimed to investigate the involvement of TLR4 in the process of skeletal muscle repair. Muscular injury was induced by injection of 0.6 mg/kg of Bothrops jararacussu snake venom in the gastrocnemius muscle of C3H/HeJ mice that express a nonfunctional TLR-4 receptor and C3H/HeN mice with functional receptor. TLR4-deficient mice had persistent muscular inflammation with few F4/80 macrophages at onset but increased MMP9 activity and collagen deposition during resolution of injury. Since such effect was not observed in the mouse strain with functional receptor it is concluded that TLR4 signaling exerts a protective role preventing from excessive muscular damage induced by B. jararacussu venom. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1396 / 1403

页数：8

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