Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives

被引：1
|
作者：
Gu, Guolong [1 ]
Lin, Haiyan [2 ]
Liu, Yajuan [3 ,4 ]
Yang, Liumeng [3 ]
Zheng, Yongtang [3 ]
Wang, Bin [1 ,5 ]
Tang, Chunlei [1 ,6 ]
Qian, Hai [1 ]
Huang, Wenlong [1 ]
机构：
[1] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Dept Biochem & Mol Biol, Nanjing 210029, Jiangsu, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech Chinese Acad, Kunming 650223, Yunnan, Peoples R China
[4] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
[5] Jiangsu Yabang Pharmaceut Grp, Ctr Technol, Changzhou 213163, Peoples R China
[6] Jiangnan Univ, Sch Med & Pharmaceut, Wuxi 214122, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2013年 / 10卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Andrographolide; Derivatives; Anti-HIV; C8166; cells; Natural products; Synthesis; ALPHA-GLUCOSIDASE INHIBITORS; IN-VITRO; BIOLOGICAL EVALUATION; AGENTS; PANICULATA; CELLS; VIVO; AIDS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
引用
收藏
页码：155 / 163
页数：9
相关论文
共 50 条
  • [31] Novel quinolone-3-carboxylic acid derivatives as anti-HIV-1 agents: design, synthesis, and biological activities
    Hajimahdi, Z.
    Zabihollahi, R.
    Aghasadeghi, M. R.
    Ashtiani, S. Hosseini
    Zarghi, A.
    MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (09) : 1861 - 1876
  • [32] Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives
    Pawar, Digamber S.
    V. Chabukswar, Vasant
    Tapase, Savita R.
    Kodam, Kisan M.
    Chabukswar, Anurudhha
    Adhav, Pravin B.
    Diwate, Balasaheb B.
    Gawali, Sunita Salunke
    Dallavalle, Sabrina
    Jagdale, Swati C.
    MEDICINAL CHEMISTRY, 2021, 17 (08) : 926 - 936
  • [33] Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation on cytotoxic activities
    Luo, Yan
    Wang, Ke
    Zhang, Meng-han
    Zhang, Da-yong
    Wu, Yang-chang
    Wu, Xiao-ming
    Hua, Wei-yi
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (11) : 2421 - 2424
  • [34] Synthesis and structure anti-inflammatory activity relationships studies of andrographolide derivatives
    Liu, Ling
    Yan, Yan
    Zheng, Lihua
    Jia, Haiyan
    Han, Guang
    NATURAL PRODUCT RESEARCH, 2020, 34 (06) : 782 - 789
  • [35] Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives
    Li, Jing
    Huang, Wenlong
    Zhang, Huibin
    Zhou, Huiping
    LETTERS IN DRUG DESIGN & DISCOVERY, 2010, 7 (03) : 176 - 181
  • [36] Design, synthesis and antibacterial activity of novel andrographolide derivatives
    Wang, Zhongli
    Yu, Pei
    Zhang, Gaoxiao
    Xu, Lipeng
    Wang, Dingyuan
    Wang, Liang
    Zeng, Xiangping
    Wang, Yuqiang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (12) : 4269 - 4274
  • [37] Design, Synthesis, Molecular Modeling and Anti-HIV Assay of Novel Quinazolinone Incorporated Coumarin Derivatives
    Safakish, Mahdieh
    Hajimahdi, Zahra
    Aghasadeghi, Mohammad R.
    Vahabpour, Rouhollah
    Zarghi, Afshin
    CURRENT HIV RESEARCH, 2020, 18 (01) : 41 - 51
  • [38] A Novel Molecular Imprint Polymer Synthesis for Solid Phase Extraction of Andrographolide
    Krishnan, Hemavathi
    Islam, A. K. M. Shafiqul
    Hamzah, Zainab
    Nadaraja, Pubalan
    Ahmad, Mohd Noor
    INDONESIAN JOURNAL OF CHEMISTRY, 2019, 19 (01) : 219 - 230
  • [39] Synthesis of novel pyrazole acetals of andrographolide and isoandrographolide as potent anticancer agents
    Rokkam, Siva Kumar
    Bhujel, Manohar
    Jain, Dolly
    Sripada, Lakshminath
    Nanduri, Srinivas
    Bajaj, Avinash
    Golakoti, Nageswara Rao
    RSC ADVANCES, 2024, 14 (36) : 26625 - 26636
  • [40] Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs
    Liu, Zhaoqiang
    Tian, Ye
    Liu, Jinghan
    Huang, Boshi
    Kang, Dongwei
    De Clercq, Erik
    Daelemans, Dirk
    Pannecouque, Christophe
    Zhan, Peng
    Liu, Xinyong
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 140 : 383 - 391
12345