Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives

被引：1
|
作者：
Gu, Guolong [1 ]
Lin, Haiyan [2 ]
Liu, Yajuan [3 ,4 ]
Yang, Liumeng [3 ]
Zheng, Yongtang [3 ]
Wang, Bin [1 ,5 ]
Tang, Chunlei [1 ,6 ]
Qian, Hai [1 ]
Huang, Wenlong [1 ]
机构：
[1] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Dept Biochem & Mol Biol, Nanjing 210029, Jiangsu, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech Chinese Acad, Kunming 650223, Yunnan, Peoples R China
[4] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
[5] Jiangsu Yabang Pharmaceut Grp, Ctr Technol, Changzhou 213163, Peoples R China
[6] Jiangnan Univ, Sch Med & Pharmaceut, Wuxi 214122, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2013年 / 10卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Andrographolide; Derivatives; Anti-HIV; C8166; cells; Natural products; Synthesis; ALPHA-GLUCOSIDASE INHIBITORS; IN-VITRO; BIOLOGICAL EVALUATION; AGENTS; PANICULATA; CELLS; VIVO; AIDS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
引用
收藏
页码：155 / 163
页数：9
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