Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives

被引：1
|
作者：
Gu, Guolong [1 ]
Lin, Haiyan [2 ]
Liu, Yajuan [3 ,4 ]
Yang, Liumeng [3 ]
Zheng, Yongtang [3 ]
Wang, Bin [1 ,5 ]
Tang, Chunlei [1 ,6 ]
Qian, Hai [1 ]
Huang, Wenlong [1 ]
机构：
[1] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Dept Biochem & Mol Biol, Nanjing 210029, Jiangsu, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech Chinese Acad, Kunming 650223, Yunnan, Peoples R China
[4] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
[5] Jiangsu Yabang Pharmaceut Grp, Ctr Technol, Changzhou 213163, Peoples R China
[6] Jiangnan Univ, Sch Med & Pharmaceut, Wuxi 214122, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2013年 / 10卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Andrographolide; Derivatives; Anti-HIV; C8166; cells; Natural products; Synthesis; ALPHA-GLUCOSIDASE INHIBITORS; IN-VITRO; BIOLOGICAL EVALUATION; AGENTS; PANICULATA; CELLS; VIVO; AIDS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.
引用
收藏
页码：155 / 163
页数：9
相关论文
共 50 条
  • [11] Recent Progress in Synthesis of Andrographolide Derivatives with Anti-tumor Activities
    Peng, Yuran
    Sun, Yicheng
    Wang, Decai
    Wei, Ping
    Ouyang, Pingkai
    Zhou, Guochun
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 35 (07) : 1451 - 1468
  • [12] Synthesis and anti-influenza virus activity evaluation of novel andrographolide derivatives
    Chunyang Zou
    Jinyu Men
    Yingjin Qu
    Chunfeng Jiang
    Yao Wang
    Lixia Chen
    Lei Yuan
    Medicinal Chemistry Research, 2022, 31 : 1959 - 1973
  • [13] Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities
    Wang, Wang
    Wu, Yanli
    Yang, Kaiyin
    Wu, Canrong
    Tang, Ruotian
    Li, Hua
    Chen, Lixia
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 173 : 282 - 293
  • [14] Synthesis and evaluation of novel arctigenin derivatives as potential anti-Toxoplasma gondii agents
    Zhang, Hai-bin
    Shen, Qing-Kun
    Wang, Hui
    Jin, Chunmei
    Jin, Chun-Mei
    Quan, Zhe-Shan
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 158 : 414 - 427
  • [15] Synthesis and biological evaluation of andrographolide analogues as anti-cancer agents
    Preet, Ranjan
    Chakraborty, Biswajit
    Siddharth, Sumit
    Mohapatra, Purusottam
    Das, Dipon
    Satapathy, Shakti Ranjan
    Das, Supriya
    Maiti, Nakul C.
    Maulik, Prakas R.
    Kundu, Chanakya Nath
    Chowdhury, Chinmay
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 85 : 95 - 106
  • [16] Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives
    Wang, Bin
    Tang, Chunlei
    Han, Yaodan
    Guo, Ruzhou
    Qian, Hai
    Huang, Wenlong
    MEDICINAL CHEMISTRY, 2012, 8 (02) : 293 - 298
  • [17] Design, synthesis, and anti-cancer evaluation of C-14 arylcarbamate derivatives of andrographolide
    Yang, Tzu-Ching
    Chiang, Yun-Jou
    Chiang, Po-Yu
    Chen, Han-Yu
    Zhuang, Kai-Ru
    Wang, Yu-Chia
    Lin, Chao-Hsiung
    Lo, Lee-Chiang
    Fu, Shu-Ling
    BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 98
  • [18] Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Antibacterial Agents
    Tang, Chunlei
    Zhang, Wenjie
    Wang, Xinyang
    Wang, Bin
    Zhu, Xiaoyun
    Huang, Dandan
    Du, Xiaoyong
    Qian, Hai
    Huang, Wenlong
    Li, Jing
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (09) : 816 - 821
  • [19] Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives
    Alafeefy, Ahmed M.
    Kadi, Adnan A.
    Al-Deeb, Omar A.
    El-Tahir, Kamal E. H.
    Al-jaber, Nabila A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) : 4947 - 4952
  • [20] Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A Review
    Qadir, Tanzeela
    Shaikh, Shoaib
    Kanth, Saadat A.
    Singh, Jyotika
    Baby, Maria
    Sharma, Praveen Kumar
    CURRENT ORGANIC CHEMISTRY, 2024, 28 (09) : 686 - 699
12345