Interaction between adipose tissue and cancer cells: role for cancer progression

被引：62

作者：

Dumas, Jean-Francois ^{[1
]}

Brisson, Lucie ^{[1
]}

机构：

[1] Univ Tours, INSERM, UMR1069, Nutr Growth & Canc, 10 Blvd Tonnelle, F-37032 Tours, France

来源：

CANCER AND METASTASIS REVIEWS | 2021年 / 40卷 / 01期

关键词：

Adipocyte; Cancer; Adipokines; Metabolism; Fatty acid; Exosome; FATTY-ACID OXIDATION; BONE-MARROW ADIPOCYTES; TUMOR PROGRESSION; LINKS OBESITY; BREAST; ADIPONECTIN; METABOLISM; LEPTIN; GROWTH; RESISTANCE;

D O I：

10.1007/s10555-020-09934-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Environment surrounding tumours are now recognized to play an important role in tumour development and progression. Among the cells found in the tumour environment, adipocytes from adipose tissue establish a vicious cycle with cancer cells to promote cancer survival, proliferation, metastasis and treatment resistance. This cycle is particularly of interest in the context of obesity, which has been found as a cancer risk factor. Cancers cells can reprogram adipocyte physiology leading to an "activated" phenotype characterized by delipidation and secretion of inflammatory adipokines. The adipocyte secretions then influence tumour growth and metastasis which has been mainly attributed to interleukin 6 (IL-6) or leptin but also to the release of fatty acids which are able to change cancer cell metabolism and signalling pathways. The aim of this review is to report recent advances in the understanding of the molecular mechanisms linking adipose tissue with cancer progression in order to propose new therapeutic strategies based on pharmacological or nutritional intervention.

引用

页码：31 / 46

页数：16

共 114 条

[21] Cancer metabolism in space and time: Beyond the Warburg effect [J].

Danhier, Pierre ;

Banski, Piotr ;

Payen, Valery L. ;

Grasso, Debora ;

Ippolito, Luigi ;

Sonveaux, Pierre ;

Porporato, Paolo E. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2017, 1858 (08) :556-572

[22] Reciprocal Interactions between Breast Tumor and Its Adipose Microenvironment Based on a 3D Adipose Equivalent Model [J].

Delort, Laetitia ;

Lequeux, Charlotte ;

Dubois, Virginie ;

Dubouloz, Alice ;

Billard, Hermine ;

Mojallal, Ali ;

Damour, Odile ;

Vasson, Marie-Paule ;

Caldefie-Chezet, Florence .

PLOS ONE, 2013, 8 (06)

[23] Adipokines as novel biomarkers and regulators of the metabolic syndrome [J].

Deng, Yingfeng ;

Scherer, Philipp E. .

YEAR IN DIABETES AND OBESITY, 2010, 1212 :E1-E19

[24] Bone marrow adipocytes promote the warburg phenotype in metastatic prostate tumors via HIF-1a activation [J].

Diedrich, Jonathan D. ;

Rajagurubandara, Erandi ;

Herroon, Mackenzie K. ;

Mahapatra, Gargi ;

Huttemann, Maik ;

Podgorski, Izabela .

ONCOTARGET, 2016, 7 (40) :64854-64877

[25] Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion [J].

Dirat, Beatrice ;

Bochet, Ludivine ;

Dabek, Marta ;

Daviaud, Daniele ;

Dauvillier, Stephanie ;

Majed, Bilal ;

Wang, Yuan Yuan ;

Meulle, Aline ;

Salles, Bernard ;

Le Gonidec, Sophie ;

Garrido, Ignacio ;

Escourrou, Ghislaine ;

Valet, Philippe ;

Muller, Catherine .

CANCER RESEARCH, 2011, 71 (07) :2455-2465

[26] Estrogen Receptor (ER)α-regulated Lipocalin 2 Expression in Adipose Tissue Links Obesity with Breast Cancer Progression [J].

Drew, Brian G. ;

Hamidi, Habib ;

Zhou, Zhenqi ;

Villanueva, Claudio J. ;

Krum, Susan A. ;

Calkin, Anna C. ;

Parks, Brian W. ;

Ribas, Vicent ;

Kalajian, Nareg Y. ;

Phun, Jennifer ;

Daraei, Pedram ;

Christofk, Heather R. ;

Hewitt, Sylvia C. ;

Korach, Kenneth S. ;

Tontonoz, Peter ;

Lusis, Aldons J. ;

Slamon, Dennis J. ;

Hurvitz, Sara A. ;

Hevener, Andrea L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (09) :5566-5581

[27] Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment [J].

Dumas, Jean-Francois ;

Brisson, Lucie ;

Chevalier, Stephan ;

Maheo, Karine ;

Fromont, Gaelle ;

Moussata, Driffa ;

Besson, Pierre ;

Roger, Sebastien .

SEMINARS IN CANCER BIOLOGY, 2017, 43 :90-110

[28] Adipocytes Cause Leukemia Cell Resistance to L-Asparaginase via Release of Glutamine [J].

Ehsanipour, Ehsan A. ;

Sheng, Xia ;

Behan, James W. ;

Wang, Xingchao ;

Butturini, Anna ;

Avramis, Vassilios I. ;

Mittelman, Steven D. .

CANCER RESEARCH, 2013, 73 (10) :2998-3006

[29] A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy [J].

Figiel, Sandy ;

Bery, Fanny ;

Chantome, Aurelie ;

Fontaine, Delphine ;

Pasqualin, Come ;

Maupoil, Veronique ;

Domingo, Isabelle ;

Guibon, Roseline ;

Bruyere, Franck ;

Potier-Cartereau, Marie ;

Vandier, Christophe ;

Fromont, Gaelle ;

Maheo, Karine .

CANCERS, 2019, 11 (11)

[30] Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in Africane-Caribbean and Caucasian patients [J].

Figiel, Sandy ;

Pinault, Michelle ;

Domingo, Isabelle ;

Guimaraes, Cyrille ;

Guibon, Roseline ;

Besson, Pierre ;

Tavernier, Elsa ;

Blanchet, Pascal ;

Multigner, Luc ;

Bruyere, Franck ;

Haillot, Olivier ;

Mathieu, Romain ;

Vincendeau, Sebastien ;

Rioux-Leclercq, Nathalie ;

Lebdai, Souhil ;

Azzouzi, Abdel-Rahmene ;

Perrouin-Verbe, Marie-Aimee ;

Fournier, Georges ;

Doucet, Laurent ;

Rigaud, Jerome ;

Renaudin, Karine ;

Maheo, Karine ;

Fromont, Gaelle .

EUROPEAN JOURNAL OF CANCER, 2018, 91 :107-115

← 1 2 3 4 5 6 7 8 9 10 →