Cytochrome c oxidase: exciting progress and remaining mysteries

被引：228

作者：

Brzezinski, Peter ^{[2
]}

Gennis, Robert B. ^{[1
]}

机构：

[1] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA

[2] Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, S-10691 Stockholm, Sweden

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2008年 / 40卷 / 05期

基金：

瑞典研究理事会; 美国国家卫生研究院;

关键词：

Oxidase; Cytochrome; Proton; Redox; Energy coupling; Pump; Heme; Copper;

D O I：

10.1007/s10863-008-9181-7

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Cytochrome c oxidase generates a proton motive force by two separate mechanisms. The first mechanism is similar to that postulated by Peter Mitchell, and is based on electrons and protons used to generate water coming from opposite sides of the membrane. The second mechanism was not initially anticipated, but is now firmly established as a proton pump. A brief review of the current state of our understanding of the proton pump of cytochrome oxidase is presented. We have come a long way since the initial observation of the pump by Marten Wikstrom in 1977, but a number of essential questions remain to be answered.

引用

页码：521 / 531

页数：11

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