Pre-concentration of non-steroidal anti-inflammatory drugs in water using dispersive liquid-liquid and single-drop microextraction with high-performance liquid chromatography

被引：41
作者：
Sarafraz-yazdi, Ali [1 ,3 ]
Assadi, Hakimeh [1 ,3 ]
Es'haghi, Zarrin [2 ,3 ]
Danesh, Noor Mohammad [3 ]
机构：
[1] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad, Iran
[2] Payame Noor Univ, Dept Chem, Tehran, Iran
[3] Ferdowsi Univ Mashhad, Res & Technol Ctr Biomol, Mashhad, Iran
来源：
JOURNAL OF SEPARATION SCIENCE | 2012年 / 35卷 / 18期
关键词：
Dispersive liquid-liquid microextraction; New combinational microextraction method; Non-steroidal anti-inflammatory drugs; Single-drop microextraction; Water samples; ELECTRON-CAPTURE DETECTION; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; PERSONAL-CARE PRODUCTS; TIME-OF-FLIGHT; WASTE-WATER; PHARMACEUTICAL RESIDUES; ENVIRONMENTAL-SAMPLES; SURFACE-WATER; DIODE-ARRAY;
D O I：
10.1002/jssc.201101099
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In the present work the combination of two liquid-phase microextraction techniques involving dispersive liquidliquid microextraction and single-drop microextraction as a new pre-concentration technique is developed for the separation and determination of acidic non-steroidal anti-inflammatory pharmaceutical compounds, namely, naproxen, diclofenac, and ibuprofen, in water samples using high-performance liquid chromatography ultra violet-detection. The extraction conditions were optimized and, under the optimal conditions, the method showed good linearity range of 0.11000 mu g L-1 (R > 0.9990), acceptable reproducibilities (relative standard deviation% = 4.58.8%), low limits of detection (0.030.2 mu g L-1), and satisfactory relative recoveries. The developed method was applied for the determination of anti-inflammatory drugs in river and waste water samples.
引用
收藏
页码：2476 / 2483
页数：8
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