Evaluation of anterior chamber parameters with spectral-domain optical coherence tomography

To evaluate several anterior chamber parameters in healthy young adults using spectral-domain optical coherence tomography and to describe the repeatability and reproducibility of this method. Prospective clinical study. Fifty-two eyes of 52 healthy volunteers were enrolled. Manual measurements of the anterior chamber angle (ACA(500) and ACA(750)), angle opening distance (AOD(500) and AOD(750)), angle-to-angle distance (ATA), anterior chamber width (ACW), and lens vault (LV) were obtained. The mean nasal ACA(500) was 44.87 +/- 12.92A degrees; ACA(750), 43.94 +/- 10.41A degrees; AOD(500), 672.54 +/- 270.19 A mu m; AOD(750,) 881.87 +/- 290.55 A mu m. The mean temporal ACA(500) was 41.46 +/- 11.20A degrees; ACA(750), 41.27 +/- 11.31A degrees; AOD(500), 603.15 +/- 232.28 A mu m; AOD(750,) 823.46 +/- 308.76 A mu m. The differences between the corresponding nasal and temporal parameters were statistically significant. The ACW was 11.97 +/- 0.42 mm, the ATA was 12.10 +/- 0.43 mm, and the LV was 3.71 +/- 232.93 A mu m. The ACA was highly associated with the LV. The intraclass correlation coefficients ranged from 0.984 to 0.999 for the intraobserver repeatability and from 0.966 to 0.998 for the interobserver reproducibility. This study assessed anterior chamber parameters in healthy young adults using spectral-domain optical coherence tomography. This technique reveals the spatial relationships of the ocular structures, provides high-resolution images, and results in high degrees of intraobserver and interobserver repeatabilities.