The pathophysiology of the intervertebral disc

被引：119

作者：

Bibby, SRS ^{[1
]}

Jones, DA ^{[1
]}

Lee, RB ^{[1
]}

Yu, J ^{[1
]}

Urban, JPG ^{[1
]}

机构：

[1] Univ Oxford, Phys Lab, Oxford OX1 3PT, England

来源：

JOINT BONE SPINE | 2001年 / 68卷 / 06期

关键词：

collagen; disk cells; disk degeneration; low back pain; proteoglycan; scoliosis;

D O I：

10.1016/S1297-319X(01)00332-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

After a review of disk structure, the pivotal role of disk cells in producing and renewing the extracellular disk matrix is emphasized. Disk cells rely on nutrients that diffuse through the vertebral endplates. Microelectrode methods have been developed to study nutrient diffusion and endplate permeability. Mechanical stimuli modify disk cell activity. Scoliosis is associated with decreased endplate permeability, a factor that may play a role in disk degeneration and scoliosis progression. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：537 / 542

页数：6

共 15 条

[1]

BUTLER WF, 1989, BIOL INTERVERTEBRAL, P84

[2] Matrix metalloproteinases in the human intervertebral disc: Role in disc degeneration and scoliosis [J].