The Role of Magnetic Resonance Imaging in Detecting Intestinal Fibrosis in Crohn's Disease

被引：3
作者：
Fiorino, Gionata [1 ]
Cesarini, Monica [2 ]
Malesci, Alberto [3 ]
Danese, Silvio [1 ]
Sorrentino, Dario [4 ,5 ,6 ]
机构：
[1] IRCCS Humanitas, IBD Ctr, I-20089 Milan, Italy
[2] Univ Rome, Rome, Italy
[3] Univ Milan, Milan, Italy
[4] Univ Queensland, Nambour, Australia
[5] Sunshine Coast Clin Sch, Nambour, Australia
[6] Univ Udine, Sch Med, DSMSC, I-33100 Udine, Italy
来源：
CURRENT DRUG TARGETS | 2012年 / 13卷 / 10期
关键词：
Crohn's disease; inflammatory bowel disease; magnetic resonance imaging; fibrosis; inflammation; intestinal-strictures; INFLAMMATORY-BOWEL-DISEASE; MR ENTEROGRAPHY; BLOOD-FLOW; CLINICAL ACTIVITY; TERMINAL ILEUM; ORAL CONTRAST; ENTEROCLYSIS; SEVERITY; CT; ANGIOGENESIS;
D O I：
10.2174/138945012802429651
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
One of the main challenges for clinicians dealing with Crohn's disease (CD) is to distinguish between inflammation and fibrosis, two sequential steps in the evolution of the intestinal disease. While inflammation is amenable to medical treatment, stricturing disease can only benefit from surgery. Magnetic resonance imaging (MRI) is a widely used tool in the diagnosis and assessment of CD. Recent data suggest that this technique might help in discriminating between fibrosis and inflammation and as such potentially guide medical decisions. In this review we will first highlight the main diagnostic techniques for CD. We will then briefly review the main mechanisms of fibrosis in this condition and the use of MRI in CD focusing on findings predictive of fibrosis and fibrotic evolution.
引用
收藏
页码：1273 / 1279
页数：7
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