Small dense low-density lipoprotein cholesterol was associated with future cardiovascular events in chronic kidney disease patients

被引：27

作者：

Shen, Hao ^{[1
]}

Xu, Yan ^{[2
]}

Lu, Jingfen ^{[1
]}

Ma, Chunfang ^{[1
]}

Zhou, Yadong ^{[1
]}

Li, Qiong ^{[1
]}

Chen, Xu ^{[1
]}

Zhu, Ao ^{[3
]}

Shen, Guorong ^{[1
]}

机构：

[1] Nantong Univ, Peoples Hosp Wujiang Dist 1, Dept Clin Lab Med, Suzhou, Peoples R China

[2] Nantong Univ, Peoples Hosp Wujiang Dist 1, Dept Nephrol, Suzhou, Peoples R China

[3] Nantong Univ, Peoples Hosp Wujiang Dist 1, Dept Geriatr, Suzhou, Peoples R China

来源：

BMC NEPHROLOGY | 2016年 / 17卷

关键词：

Chronic kidney disease; Cardiovascular diseases; Lipids; sdLDL-C; CORONARY-HEART-DISEASE; PARTICLE DIAMETER; FOLLOW-UP; RISK; BIOMARKERS; INFARCTION; COMMITTEE; OUTCOMES; COHORT; SIZE;

D O I：

10.1186/s12882-016-0358-8

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Cardiovascular disease (CVD) is often comorbid with chronic kidney disease (CKD). Small low-density lipoprotein cholesterol (sdLDL-C) has also been found to increase risk for CVD. The goal of the present study was to determine the nature of the relationship between sdLDL-C concentration and CVD in patients with CKD. Methods: One-hundred and forty-five subjects (113 men and 32 women) with CKD (Stage 3 and Stage 4) participated this retrospective study. The concentration of sdLDL-C was measured in samples from 145 CKD patients between 2010 and 2012 during a four-year follow-up period. Results: A total of eight fatal cardiovascular events (CVs) and 46 nonfatal CVs were registered in the four-year follow-up period. Multivariate Cox regression analysis showed that sdLDL-C [1.278, 95 % (1.019-1.598)] and sdLDL-C/LDL-C [2.456, 95 % (1.421-15.784)], at final observation, were independent risks of CVs. A Kaplan-Meier survival analysis showed that patients with sdLDL-C > 38 mg/dl (logrank: 4.375, P = 0.037), and sdLDL-C/LDL-C ratio > 0.3 levels (logrank: 11. 94, P = 0.018) were at increased risk for CVs. Conclusion: The results of this study indicated that for patients suffering CKD, a significant relationship exists between an elevated sdLDL-C concentration and the risk of cardiovascular disease.

引用

页码：1 / 7

页数：7

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