Distribution of beta-amyloid in the canine brain

被引：28
作者：
Hou, Y
White, RG
Bobik, M
Marks, JS
Russell, MJ
机构：
[1] Dept. of Anesth. and Otolaryngology, University of California, Davis, CA 95616
来源：
NEUROREPORT | 1997年 / 8卷 / 04期
关键词：
aging; beta-amyloid; Alzheimer's disease; animal model; brain dog; distribution;
D O I：
10.1097/00001756-199703030-00038
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE distribution of amyloid-beta protein (A beta) in the canine brain was demonstrated by immunochemistry on serially sectioned tissues from 10 aged mixed breed dogs. Summation of quantitative data and relegation to anatomical sites for the 10 dogs showed A beta to be widely distributed in the cortex and hippocampus while completely absent in the brain stem and cerebellum. The highest density of A beta was in the dentate gyrus of the hippocampus. Cortical areas exhibiting the greatest A beta deposition were the posterior and medial suprasylvius gyrus and the proreus gyrus of the frontal lobe. Unlike humans the canine entorhinal cortex, amygdala, basal ganglia and olfactory bulbs were rarely affected. This suggested that the highly developed olfactory pathways of the canine are generally spared from A beta deposition.
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收藏
页码：1009 / 1012
页数：4
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