Yeast chemical genomics and drug discovery: an update

被引：66

作者：

Hoon, Shawn ^{[2
]}

Onge, Robert P. St. ^{[3
]}

Giaever, Guri ^{[1
,4
,5
]}

Nislow, Corey ^{[1
,5
,6
]}

机构：

[1] Univ Toronto, Donnelley Ctr Cellular Biomol Res, Toronto, ON M5S 3E1, Canada

[2] Stanford Univ, Dept Genet, Palo Alto, CA 94305 USA

[3] Stanford Univ, Stanford Genome Technol Ctr, Dept Biochem, Palo Alto, CA 94304 USA

[4] Univ Toronto, Dept Pharm, Toronto, ON M5S 3E1, Canada

[5] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

[6] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5S 3E1, Canada

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2008年 / 29卷 / 10期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tips.2008.07.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Saccharomyces cerevisiae sequencing project (the first eukaryotic genome decoded) was completed in 1995 and, subsequently, the first version of the yeast knockout collection was made available in 2002. Since then, many diverse studies have applied these resources to understand drug mechanism of action and to identify novel drug targets and target pathways. In this update of an earlier review, we present a snapshot of the current state of chemical genomic approaches in yeast, propose a set of integrated chemical genomic assays to move the field forward and consider its near-term future.

引用

页码：499 / 504

页数：6

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