D-Cycloserine Facilitates Extinction of Conditioned Alcohol-Seeking Behaviour in Rats

被引：44
作者：
Vengeliene, Valentina [1 ]
Kiefer, Falk [2 ]
Spanagel, Rainer [1 ]
机构：
[1] Univ Heidelberg, CIMH, Dept Psychopharmacol, D-68159 Mannheim, Germany
[2] Univ Heidelberg, CIMH, Dept Addict Behav & Addict Med, D-68159 Mannheim, Germany
来源：
ALCOHOL AND ALCOHOLISM | 2008年 / 43卷 / 06期
关键词：
D O I：
10.1093/alcalc/agn067
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Aims: The aim of the present study was to examine the influence of partial NMDA receptor agonist D-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour. Methods: For this purpose, rats were administered with DCS 60 min before each successive extinction session. Resumption of alcohol responding was carried out 1 day after the final extinction session. Results: We demonstrate that treatment of rats with 5 mg/kg of DCS was capable in facilitating extinction of conditioned alcohol-seeking behaviour, which subsequently reduced the resumption of extinguished operant responding. Conclusions: Our study suggests a good rationale for the development of new add-on medications for exposure-based psychotherapy so as to extinguish drug-conditioned appetitive memories in alcohol-dependent patients.
引用
收藏
页码：626 / 629
页数：4
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