Regulation of Cryptococcus neoformans capsule size is mediated at the polymer level

被引:39
作者
Yoneda, Aki [1 ]
Doering, Tamara L. [1 ]
机构
[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
关键词
D O I
10.1128/EC.00437-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The fungal pathogen Cryptococcus neoformans regulates its polysaccharide capsule depending on environmental stimuli. To investigate whether capsule polymers change under different growth conditions, we analyzed shed capsules at physiological concentrations without physical perturbation. Our results indicate that regulation of capsule size is mediated at the level of individual polysaccharide molecules.
引用
收藏
页码:546 / 549
页数:4
相关论文
共 40 条
[1]   Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans [J].
Bahn, YS ;
Kojima, K ;
Cox, GM ;
Heitman, J .
MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (05) :2285-2300
[2]  
BROWN T, 1999, CURRENT PROTOCOLS MO, V1
[3]   Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans [J].
Cramer, Kari L. ;
Gerrald, Quincy D. ;
Nichols, Connie B. ;
Price, Michael S. ;
Alspaugh, J. Andrew .
EUKARYOTIC CELL, 2006, 5 (07) :1147-1156
[4]  
*CSH PROT, 2007, DNA LOAD BUFF 6X, DOI DOI 10.1101/PDB.REC11045
[5]  
DESHAW M, 1995, CLIN EXP IMMUNOL, V99, P425, DOI 10.1111/j.1365-2249.1995.tb05568.x
[6]   Cryptococcus neoformans capsule structure evolution in vitro and during murine infection [J].
Garcia-Hermoso, D ;
Dromer, F ;
Janbon, G .
INFECTION AND IMMUNITY, 2004, 72 (06) :3359-3365
[7]   Molecular architecture of the Cryptococcus neoformans capsule [J].
Gates, MA ;
Thorkildson, P ;
Kozel, TR .
MOLECULAR MICROBIOLOGY, 2004, 52 (01) :13-24
[8]   VIRULENCE OF CRYPTOCOCCUS-NEOFORMANS - REGULATION OF CAPSULE SYNTHESIS BY CARBON-DIOXIDE [J].
GRANGER, DL ;
PERFECT, JR ;
DURACK, DT .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (02) :508-516
[9]   UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus Cryptococcus neoformans [J].
Griffith, CL ;
Klutts, JS ;
Zhang, LJ ;
Levery, SB ;
Doering, TL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (49) :51669-51676
[10]   Phenotypic switching in Cryptococcus neoformans [J].
Guerrero, A ;
Jain, N ;
Goldman, DL ;
Fries, BC .
MICROBIOLOGY-SGM, 2006, 152 :3-9