High-risk myeloma and minimal residual disease postautologous-HSCT predict worse outcomes

被引：16

作者：

Hu, Bei ^{[1
]}

Thall, Peter ^{[2
]}

Milton, Denai R. ^{[2
]}

Sasaki, Koji ^{[3
]}

Bashir, Qaiser ^{[4
]}

Shah, Nina ^{[4
]}

Patel, Krina ^{[6
]}

Popat, Uday ^{[4
]}

Hosing, Chitra ^{[4
]}

Nieto, Yago ^{[4
]}

Lin, Pei ^{[5
]}

Delgado, Ruby ^{[4
]}

Jorgensen, Jeffrey ^{[5
]}

Manasanch, Elisabet ^{[6
]}

Weber, Donna ^{[6
]}

Thomas, Sheeba ^{[6
]}

Orlowski, Robert Z. ^{[6
]}

Champlin, Richard ^{[4
]}

Qazilbash, Muzaffar H. ^{[4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Canc Med, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Biostat, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, 1515 Holcombe Blvd Unit 428, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Hematopathol, Houston, TX 77030 USA

[6] Univ Texas MD Anderson Canc Ctr, Lymphoma & Myeloma, Houston, TX 77030 USA

来源：

LEUKEMIA & LYMPHOMA | 2019年 / 60卷 / 02期

关键词：

Multiple myeloma; autologous stem cell transplant; minimal residual disease; flow cytometry; high-risk cytogenetics; nearest neighbor matching; STEM-CELL TRANSPLANTATION; DIAGNOSED MULTIPLE-MYELOMA; MULTIPARAMETER FLOW-CYTOMETRY; BORTEZOMIB PLUS DEXAMETHASONE; DEEP-SEQUENCING METHOD; IN-SITU HYBRIDIZATION; MAINTENANCE THERAPY; COMPLETE RESPONSE; INTERGROUPE FRANCOPHONE; THALIDOMIDE IMPROVES;

D O I：

10.1080/10428194.2018.1485908

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of our study was to determine the impact of high-risk disease (HRD) and MRD on outcomes in myeloma patients receiving bortezomib-based induction followed by autologous hematopoietic stem cell transplant (auto-HSCT). HRD included t(4:14), t(14;16), del 17p, del 1p and/or amplification 1q by cytogenetics/FISH; all others were standard-risk disease (SRD). A subset of 165 newly diagnosed myeloma patients in a 2:1 ratio of HRD:SRD was generated using propensity score based nearest neighbor matching. Multiparametric flow cytometry (MFC) was used to detect MRD after auto-HSCT in select patients. MRD+ status at 3 months post auto-HSCT (hazard ratio (HR = 4.23, p = .028) and HRD (HR = 1.72, p = .026) were associated with a shorter PFS. Similarly, MRD+ 3 months post auto-HSCT (HR = 6.93, p = .08) and HRD (HR = 3.54, p < .001) and were associated with a shorter OS. Despite bortezomib-based induction, upfront auto-HSCT, and use of maintenance therapy, PFS and OS remained worse in MRD+ and HRD patients.

引用

页码：442 / 452

页数：11

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