Calcium- and activity-dependent synaptic plasticity

被引：508
作者：
Zucker, RS [1 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1999年 / 9卷 / 03期
关键词：
D O I：
10.1016/S0959-4388(99)80045-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Calcium ions play crucial signaling roles in many forms of activity-dependent synaptic plasticity. Recent presynaptic [Ca2+](i) measurements and manipulation of presynaptic exogenous buffers reveal roles for residual [Ca2+](i) following conditioning stimulation in all phases of short-term synaptic enhancement. Pharmacological manipulations implicate mitochondria in post-tetanic potentiation. New evidence supports an influence of Ca2+ in replacing depleted vesicles after synaptic depression. In addition, high-resolution measurements of [Ca2+](i) in dendritic spines show how Ca2+ can encode the precise relative timing of presynaptic input and postsynaptic activity and generate long-term synaptic modifications of opposite polarity.
引用
收藏
页码：305 / 313
页数：9
相关论文
共 103 条
[1]   Polarity of long-term synaptic gain change is related to postsynaptic spike firing at a cerebellar inhibitory synapse [J].
Aizenman, CD ;
Manis, PB ;
Linden, DJ .
NEURON, 1998, 21 (04) :827-835
[2]  
Armitage BA, 1998, J NEUROSCI, V18, P8770
[3]   LONG-TERM DEPRESSION OF EXCITATORY SYNAPTIC TRANSMISSION AND ITS RELATIONSHIP TO LONG-TERM POTENTIATION [J].
ARTOLA, A ;
SINGER, W .
TRENDS IN NEUROSCIENCES, 1993, 16 (11) :480-487
[4]  
Atluri PP, 1998, J NEUROSCI, V18, P8214
[5]  
Atluri PP, 1996, J NEUROSCI, V16, P5661
[6]   Involvement of pre- and postsynaptic mechanisms in posttetanic potentiation at Aplysia synapses [J].
Bao, JX ;
Kandel, ER ;
Hawkins, RD .
SCIENCE, 1997, 275 (5302) :969-973
[7]  
Bear Mark F., 1994, Current Opinion in Neurobiology, V4, P389, DOI 10.1016/0959-4388(94)90101-5
[8]   A simple model of transmitter release and facilitation [J].
Bertram, R .
NEURAL COMPUTATION, 1997, 9 (03) :515-523
[9]   Single-domain/bound calcium hypothesis of transmitter release and facilitation [J].
Bertram, R ;
Sherman, A ;
Stanley, EF .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 75 (05) :1919-1931
[10]   Synaptic modifications in cultured hippocampal neurons: Dependence on spike timing, synaptic strength, and postsynaptic cell type [J].
Bi, GQ ;
Poo, MM .
JOURNAL OF NEUROSCIENCE, 1998, 18 (24) :10464-10472
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