Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas

被引：109

作者：

Ahn, KS ^{[1
]}

Sim, WS ^{[1
]}

Kim, IH ^{[1
]}

机构：

[1] KOREA UNIV,DEPT BIOL,SEOUL 136701,SOUTH KOREA

来源：

PLANTA MEDICA | 1996年 / 62卷 / 01期

关键词：

Angelica gigas Nakai; Umbelliferae; decursin; cytotoxic activity; protein kinase C activation; LEUKEMIA-CELLS; PHORBOL ESTER; BRYOSTATIN-1;

D O I：

10.1055/s-2006-957785

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A cytotoxic compound was purified hem the root of Angelica gigas Nakai by silica gel chromatography and preparative HPLC. As a result of the struc ture analysis by mass, IR, H-1-NMR, and C-13-NMR spectrometry, the effective compound was identified as decursin, a pyranocoumarin characterized originally from Angelica decursiva Fr. et Sav. In vitro cytotoxicity testing showed that decursin displayed toxic activity against various human cancer cell lines, for which the EDS, of decursin was about 5-16 mu g/ml. On the other hand, decursin displayed relatively low cytotoxicity against normal fibroblasts. Decursin also activated protein kinase C (PKC) in vitro, which indicates that the cytotoxic activity of decursin may be related to the protein kinase C activation.

引用

页码：7 / 9

页数：3

共 16 条

[1]

AHN KS, 1995, J MICROBIOL BIOTECHN, V5, P105

[2]

[Anonymous], PHARMACOGNOSY

[3]

Blumberg P.M., 1984, MECH TUMOR PROMOTION, V3, P143

[4]

GESHER A, 1989, ANTI-CANCER DRUG DES, V4, P93

[5]

HANNUN YA, 1985, J BIOL CHEM, V260, P39

[6]

HATA K, 1966, TETRAHEDRON LETT, P1461

[7]

HOCEVAR BA, 1991, J BIOL CHEM, V266, P28

[8]

JI HJ, 1970, KOR J PHARM, V1, P25

[9]

KENNEDY MJ, 1992, CANCER RES, V52, P1278

[10] BRYOSTATIN, AN ACTIVATOR OF THE CALCIUM PHOSPHOLIPID-DEPENDENT PROTEIN-KINASE, BLOCKS PHORBOL ESTER-INDUCED DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA-CELLS HL-60 [J].

KRAFT, AS ;

SMITH, JB ;

BERKOW, RL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (05) :1334-1338

← 1 2 →