GABA system dysfunction in autism and related disorders: From synapse to symptoms

被引：319

作者：

Coghlan, Suzanne ^{[1
]}

Horder, Jamie ^{[1
]}

Inkster, Becky ^{[2
]}

Mendez, M. Andreina ^{[1
]}

Murphy, Declan G. ^{[1
]}

Nutt, David J. ^{[3
]}

机构：

[1] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London SE5 8AF, England

[2] Univ Cambridge, Dept Psychiat, Cambridge CB2 8AH, England

[3] Univ London Imperial Coll Sci Technol & Med, Ctr Pharmacol & Therapeut, Neuropsychopharmacol Unit, Div Expt Med, London W12 0NN, England

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2012年 / 36卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

GABA; Autism spectrum disorders; GABA(A) receptor; Inhibitory interneurons; Autism; Fragile X Syndrome; Rett Syndrome; Foetal Anticonvulsant Syndrome; MENTAL-RETARDATION PROTEIN; CEREBELLAR PURKINJE-CELLS; GAMMA-AMINOBUTYRIC-ACID; RECEPTOR SUBUNIT GENES; DE-NOVO MUTATIONS; MOUSE MODEL; SPECTRUM DISORDERS; RETT-SYNDROME; BENZODIAZEPINE-RECEPTOR; CORTICAL INHIBITION;

D O I：

10.1016/j.neubiorev.2012.07.005

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Autism spectrum disorders (ASDs) are neurodevelopmental syndromes characterised by repetitive behaviours and restricted interests, impairments in social behaviour and relations, and in language and communication. These symptoms are also observed in a number of developmental disorders of known origin, including Fragile X Syndrome, Rett Syndrome, and Foetal Anticonvulsant Syndrome. While these conditions have diverse etiologies, and poorly understood pathologies, emerging evidence suggests that they may all be linked to dysfunction in particular aspects of GABAergic inhibitory signalling in the brain. We review evidence from genetics, molecular neurobiology and systems neuroscience relating to the role of GABA in these conditions. We conclude by discussing how these deficits may relate to the specific symptoms observed. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2044 / 2055

页数：12

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