Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats

被引：65

作者：

Liang, X

Wang, YZ

Liu, J

Luo, XT

Ye, Y

Zhu, XZ

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, Dept Pharmacol, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China

来源：

LIFE SCIENCES | 2005年 / 78卷 / 04期

关键词：

paconiflorin (PF); middle cerebral artery occlusion (MCAO); tongue protrusion (TP); water maze;

D O I：

10.1016/j.lfs.2005.04.069

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In the present study, the effects of paeoniflorin (PF), a characteristic monoterpene glucoside isolated from Paeoniae Radix, on cerebral infarction, neurological symptoms, tongue protrusion (TP) and performance in the water maze were examined at the chronic stage (4 weeks) of transient cerebral ischemia using a rat middle cerebral artery occlusion (MCAO) model. One-day (10 mg/kg, twice, s.c.) or seven-day (2.5 -10 mg/kg, twice a day, s.c.) injection of PF significantly reduced the infarct volume as well as ameliorated the deficits in neurological symptoms caused by transient MCAO at chronic stage. Transient MCAO also induced impairments in TP and performance in the water maze. Treatment with PF was able to reverse or alleviate these impairments. These results indicate that PF may be effective for treatment of stroke. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：413 / 420

页数：8

共 29 条

[11] REVERSIBLE MIDDLE CEREBRAL-ARTERY OCCLUSION WITHOUT CRANIECTOMY IN RATS [J].