Role of Helicobacter pylori and gastric cancer in Japan

被引：0
作者：
Uemura, N [1 ]
机构：
[1] Int Med Ctr Japan, Dept Gastroenterol, Tokyo, Japan
来源：
Proceedings of the 6th International Gastric Cancer Congress | 2005年
关键词：
SUBSEQUENT DEVELOPMENT; ENDOSCOPIC RESECTION; ATROPHIC GASTRITIS; ERADICATION; INFECTION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have published a long-term follow-up study to investigate the development of gastric cancer, also eradication trial in the patients whose gastric cancer was removed by endoscopic mucosal resection (EMR). 1526 patients who underwent endoscopy and were assessed as to the presence of H. pylori infection by histology, rapid urease test and serology. Follow-up endoscopy detected no gastric cancer in negative patients (n=280). On the other hand, after 8 years of follow-up, gastric cancers were discovered in 36 of the 1246 infected patients. Endoscopy after EMR detected a new gastric cancer in only 2 patients in eradication group. On the other hand after 7 years of follow up, in 11 (16%) of the 67 patients in non-treated, new cancer was discovered.The above results suggest that the development of gastric cancer is caused by H. pylori-associated gastritis. Eradication improved active gastritis and at the same time might prevent gastric cancer.
引用
收藏
页码：75 / 82
页数：8
相关论文
共 19 条
  • [11] Satoh K, 1998, HELICOBACTER, V3, P236
  • [12] MECHANISM FOR AMMONIA-INDUCED PROMOTION OF GASTRIC CARCINOGENESIS IN RATS[J]. TSUJII, M;KAWANO, S;TSUJI, S;TAKEI, Y;TAMURA, K;FUSAMOTO, H;KAMADA, T. CARCINOGENESIS, 1995(03)
  • [13] Helicobacter pylori infection and the development of gastric cancer.[J]. Uemura, N;Okamoto, S;Yamamoto, S;Matsumura, N;Yamaguchi, S;Yamakido, M;Taniyama, K;Sasaki, N;Schlemper, RJ. NEW ENGLAND JOURNAL OF MEDICINE, 2001(11)
  • [14] The magnitude of association between Helicobacter pylori infection and the development of gastric cancer[J]. Uemura, N. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2002(08)
  • [15] Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer in japan[J]. Uemura, N;Okamoto, S. GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2000(04)
  • [16] Uemura N, 1997, CANCER EPIDEM BIOMAR, V6, P639
  • [17] Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China -: A randomized controlled trial[J]. Wong, BCY;Lam, SK;Wong, WM;Chen, JS;Zheng, TT;Feng, RE;Lai, KC;Hu, WHC;Yuen, ST;Leung, SY;Fong, DYT;Ho, J;Ching, CK;Chen, JS. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004(02)
  • [18] IMPROVED FOLD WIDTH AND INCREASED ACID-SECRETION AFTER ERADICATION OF THE ORGANISM IN HELICOBACTER-PYLORI-ASSOCIATED ENLARGED FOLD GASTRITIS[J]. YASUNAGA, Y;SHINOMURA, Y;KANAYAMA, S;YABU, M;NAKANISHI, T;MIYAZAKI, Y;MURAYAMA, Y;BONILLAPALACIOS, JJ;MATSUZAWA, Y. GUT, 1994(11)
  • [19] ZANG QB, 1997, CLIN SCI, V92, P69
12