Base-promoted amide synthesis from aliphatic amines and ynones as acylation agents through C-C bond cleavage

被引：20
|
作者：
Cheng, Guolin [1 ]
Lv, Weiwei [1 ]
Kuai, Changsheng [1 ]
Wen, Si [1 ]
Xiao, Shangyun [1 ]
机构：
[1] Huaqiao Univ, Coll Mat Sci & Engn, Xiamen 361021, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 14期
关键词：
ALPHA-KETO ACIDS; CONJUGATED YNONES; DECARBOXYLATIVE AMIDATION; CASCADE REACTION; ALKYNYL IMINES; TRIPLE BOND; ACTIVATION; DECARBONYLATION; ALDEHYDES; ACCESS;
D O I：
10.1039/c7cc09310a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new protocol for the synthesis of amides via base-promoted cleavage of the C(sp)-C(CO) bond of ynones with aliphatic primary and secondary amines under transition-metal-, ligand-, and oxidant-free conditions has been developed. This method exhibits a wide substrate scope, high functional group tolerance and exclusive chemoselectivity, as well as mild reaction conditions.
引用
收藏
页码：1726 / 1729
页数：4
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