Base-promoted amide synthesis from aliphatic amines and ynones as acylation agents through C-C bond cleavage

被引：20

作者：

Cheng, Guolin ^{[1
]}

Lv, Weiwei ^{[1
]}

Kuai, Changsheng ^{[1
]}

Wen, Si ^{[1
]}

Xiao, Shangyun ^{[1
]}

机构：

[1] Huaqiao Univ, Coll Mat Sci & Engn, Xiamen 361021, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 14期

关键词：

ALPHA-KETO ACIDS; CONJUGATED YNONES; DECARBOXYLATIVE AMIDATION; CASCADE REACTION; ALKYNYL IMINES; TRIPLE BOND; ACTIVATION; DECARBONYLATION; ALDEHYDES; ACCESS;

D O I：

10.1039/c7cc09310a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new protocol for the synthesis of amides via base-promoted cleavage of the C(sp)-C(CO) bond of ynones with aliphatic primary and secondary amines under transition-metal-, ligand-, and oxidant-free conditions has been developed. This method exhibits a wide substrate scope, high functional group tolerance and exclusive chemoselectivity, as well as mild reaction conditions.

引用

页码：1726 / 1729

页数：4

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