CELLULAR AND MOLECULAR SPECIFICITY OF PITUITARY GLAND PHYSIOLOGY

被引：88

作者：

Perez-Castro, Carolina

Renner, Ulrich

Haedo, Mariana R.

Stalla, Gunter K.

Arzt, Eduardo ^{[1
]}

机构：

[1] UBA, FCEN, Lab Fisiol & Biol Mol, Dept Fisiol Biol Mol & Celular, RA-1428 Buenos Aires, DF, Argentina

来源：

PHYSIOLOGICAL REVIEWS | 2012年 / 92卷 / 01期

关键词：

ENDOTHELIAL GROWTH-FACTOR; FOLLICULO-STELLATE CELLS; GONADOTROPIN-RELEASING-HORMONE; TUMOR-TRANSFORMING GENE; LEUKEMIA-INHIBITORY FACTOR; ORPHAN NUCLEAR RECEPTORS; MESSENGER-RIBONUCLEIC-ACID; PROTEIN-KINASE-A; 3'; 5'-CYCLIC ADENOSINE-MONOPHOSPHATE; GLUCOCORTICOID RESPONSE ELEMENT;

D O I：

10.1152/physrev.00003.2011

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Perez-Castro C, Renner U, Haedo MR, Stalla GK, Arzt E. Cellular and Molecular Specificity of Pituitary Gland Physiology. Physiol Rev 92: 1-38, 2012; doi: 10.1152/physrev.00003.2011.-The anterior pituitary gland has the ability to respond to complex signals derived from central and peripheral systems. Perception of these signals and their integration are mediated by cell interactions and cross-talk of multiple signaling transduction pathways and transcriptional regulatory networks that cooperate for hormone secretion, cell plasticity, and ultimately specific pituitary responses that are essential for an appropriate physiological response. We discuss the physiopathological and molecular mechanisms related to this integrative regulatory system of the anterior pituitary gland and how it contributes to modulate the gland functions and impacts on body homeostasis.

引用

页码：1 / 38

页数：38

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