Effect of aqueous extract of Commiphora opobalsamum on blood pressure and heart rate in rats

被引：33
作者：
AbdulGhani, AS
Amin, R
机构：
[1] Biology and Biochemistry Department, Faculty of Science, Birzeit University, Birzeit, West Bank
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1997年 / 57卷 / 03期
关键词：
Commiphora opobalsamum; blood pressure; heart rate; cholinergic receptors; atropine;
D O I：
10.1016/S0378-8741(97)00063-9
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The cardiovascular effects of aqueous extracts from the branches of Commiphora opobalsamum tree were investigated. The intravenous administration of 4 mg/kg of the aqueous extract depressed systemic arterial blood pressure by 20% (P < 0.01) and reduced heart rate of anaesthetised rats by 14% (P < 0.05). The hypotensive and the bradycardiac effects were immediate and in a dose related manner. The hypotensive effect of C. opobalsamum was inhibited by the pretreatment with atropine sulfate (1-4 mg/kg). These results suggest that the hypotensive effect of C. opobalsamum is due to the activation of muscarinic cholinergic receptors. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：219 / 222
页数：4
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