Neuroimmune modulation of pain and regenerative pain medicine

被引：27
作者：
Buchheit, Thomas [1 ,2 ]
Huh, Yul [1 ,3 ]
Maixner, William [1 ]
Cheng, Jianguo [4 ,5 ]
Ji, Ru-Rong [1 ,3 ,6 ]
机构：
[1] Duke Univ, Med Ctr, Dept Anesthesiol, Ctr Translat Pain Med, Durham, NC 27710 USA
[2] Durham Vet Affairs Hlth Care Syst, Anesthesiol Serv, Durham, NC USA
[3] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA
[4] Cleveland Clin, Dept Pain Management, Cleveland, OH 44106 USA
[5] Cleveland Clin, Dept Neurosci, Cleveland, OH 44106 USA
[6] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2020年 / 130卷 / 05期
关键词：
PLATELET-RICH PLASMA; MESENCHYMAL STEM-CELLS; AUTOLOGOUS CONDITIONED SERUM; INTERLEUKIN-1 RECEPTOR ANTAGONIST; RANDOMIZED CONTROLLED-TRIAL; INTERVERTEBRAL DISC REPAIR; ACTIVATED PROTEIN-KINASE; SPINAL-CORD MICROGLIA; ROOT GANGLION NEURONS; BONE-MARROW-CELLS;
D O I：
10.1172/JCI134439
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Regenerative pain medicine, which seeks to harness the body's own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.
引用
收藏
页码：2164 / 2176
页数：13
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