Synthesis of macrocycles containing 1,3,4-oxadiazole and pyridine moieties

被引：7
|
作者：
Poojari, Subba [1 ]
Naik, P. Parameshwar [2 ]
Krishnamurthy, G. [2 ]
机构：
[1] Syngene Int Ltd, Bangalore 560099, Karnataka, India
[2] Sahyadri Sci Coll Autonomous, Dept PG Studies & Res Chem, Shimoga 577203, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 02期
关键词：
Macrocycles; Oxadiazoles; Pyridine; Aminoacids; PEPTIDES;
D O I：
10.1016/j.tetlet.2013.08.099
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of peptide-like 25-28 membered macrocycles containing 1,3,4-oxadiazoles and pyridines bearing a chiral center scaffold have been synthesized by using known coupling reagents and common protecting groups. The yield of the purified macrocycles was poor on an average, yet it seems to be independent of amino acid substitution or stereochemistry. These macrocycles represent a new class of structures for further development and for future application in high-throughput screening against a variety of biological targets. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：305 / 309
页数：5
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