The return of the nucleus: transcriptional and epigenetic control of autophagy

被引：384

作者：

Fullgrabe, Jens ^{[1
]}

Klionsky, Daniel J. ^{[2
,3
]}

Joseph, Bertrand ^{[1
]}

机构：

[1] Karolinska Inst, Canc Ctr Karolinska, Dept Oncol Pathol, S-17176 Stockholm, Sweden

[2] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2014年 / 15卷 / 01期

基金：

瑞典研究理事会;

关键词：

HISTONE DEACETYLASE INHIBITORS; REGULATES GENE-EXPRESSION; NF-KAPPA-B; SIGNALING PATHWAYS; SUPPRESSES AUTOPHAGY; H4K16; ACETYLATION; MYELOID-LEUKEMIA; MAMMALIAN TARGET; MTOR INHIBITION; CYTOSOLIC FOXO1;

D O I：

10.1038/nrm3716

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigenetic network that regulates autophagy. The identification of tightly controlled transcription factors (such as TFEB and ZKSCAN3), microRNAs and histone marks (especially acetylated Lys16 of histone 4 (H4K16ac) and dimethylated H3K9 (H3K9me2)) associated with the autophagic process offers an attractive conceptual framework to understand the short-term transcriptional response and potential long-term responses to autophagy.

引用

收藏

页码：65 / 74

页数：10

相关论文

共 147 条

[1] miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells [J].

Abe, Wakana ;

Nasu, Kaei ;

Nakada, Chisato ;

Kawano, Yukie ;

Moriyama, Masatsugu ;

Narahara, Hisashi .

HUMAN REPRODUCTION, 2013, 28 (03) :750-761

[2] Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors [J].

Bao, Jianjun ;

Sack, Michael N. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2010, 67 (18) :3073-3087

[3] Ume6 transcription factor is part of a signaling cascade that regulates autophagy [J].

Bartholomew, Clinton R. ;

Suzuki, Tsukasa ;

Du, Zhou ;

Backues, Steven K. ;

Jin, Meiyan ;

Lynch-Day, Melinda A. ;

Umekawa, Midori ;

Kamath, Avani ;

Zhao, Mantong ;

Xie, Zhiping ;

Inoki, Ken ;

Klionsky, Daniel J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (28) :11206-11210

[4] The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors [J].

Beck, T ;

Hall, MN .

NATURE, 1999, 402 (6762) :689-692

[5] Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains [J].

Bellot, Gregory ;

Garcia-Medina, Raquel ;

Gounon, Pierre ;

Chiche, Johanna ;

Roux, Daniele ;

Pouyssegur, Jacques ;

Mazure, Nathalie M. .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (10) :2570-2581

[6] Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases [J].

Bertram, PG ;

Choi, JH ;

Carvalho, J ;

Ai, WD ;

Zeng, CB ;

Chan, TF ;

Zheng, XFS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) :35727-35733

[7] Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses [J].

Broz, Daniela Kenzelmann ;

Mello, Stephano Spano ;

Bieging, Kathryn T. ;

Jiang, Dadi ;

Dusek, Rachel L. ;

Brady, Colleen A. ;

Sidow, Arend ;

Attardi, Laura D. .

GENES & DEVELOPMENT, 2013, 27 (09) :1016-1031

[8] miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death [J].

Bryant, Adam ;

Palma, Catalina A. ;

Jayaswal, Vivek ;

Yang, Yee Wa ;

Lutherborrow, Mark ;

Ma, David D. F. .

MOLECULAR CANCER, 2012, 11

[9] Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy [J].

Cao, Dian J. ;

Wang, Zhao V. ;

Battiprolu, Pavan K. ;

Jiang, Nan ;

Morales, Cyndi R. ;

Kong, Yongli ;

Rothermel, Beverly A. ;

Gillette, Thomas G. ;

Hill, Joseph A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (10) :4123-4128

[10] The TOR signaling cascade regulates gene expression in response to nutrients [J].

Cardenas, ME ;

Cutler, NS ;

Lorenz, MC ;

Di Como, CJ ;

Heitman, J .

GENES & DEVELOPMENT, 1999, 13 (24) :3271-3279

← 1 2 3 4 5 6 7 8 9 10 →