Catalyst-free concise synthesis of imidazo[1,2-a]pyrrolo[3,4-e]pyridine derivatives

被引：24

作者：

Chen, Xuebing ^{[1
]}

Zhu, Li ^{[1
]}

Fang, Li ^{[1
]}

Yan, Shengjiao ^{[1
]}

Lin, Jun ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 20期

关键词：

HETEROCYCLIC KETENE AMINALS; B-2 RECEPTOR ANTAGONISTS; BIOLOGICAL EVALUATION; CASCADE REACTION; SOLVENT-FREE; EFFICIENT; INHIBITORS; IDENTIFICATION; DISCOVERY; PYRIDINES;

D O I：

10.1039/c3ra45485a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An eco-benign and highly efficient aza-ene reaction for preparing imidazo[1,2-a]pyrrolo[3,4-e]pyridine derivatives from heterocyclic ketene aminals (HKAs) and 2,3-dioxopyrrolidines has been developed in environmentally benign solvent systems, as well as in the absence of any catalyst. The procedures feature excellent yields, short reaction times, a convenient one-pot method, and simple purification that not only minimise the generation of waste but also simplify the work-up procedure.

引用

页码：9926 / 9934

页数：9

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