Novel high-docosahexaenoic-acid tuna oil supplementation modulates gut microbiota and alleviates obesity in high-fat diet mice

被引:46
作者
Zhang, Jing [1 ,2 ,3 ]
Yi, Congmin [1 ,2 ]
Han, Jiaojiao [1 ,2 ]
Ming, Tinghong [1 ,2 ]
Zhou, Jun [1 ,2 ]
Lu, Chenyang [1 ,2 ]
Li, Ye [1 ,2 ]
Su, Xiurong [1 ,2 ]
机构
[1] Ningbo Univ, State Key Lab Qual & Safety Argoprod, 169 Qixing South Rd, Ningbo, Peoples R China
[2] Ningbo Univ, Sch Marine Sci, Ningbo, Peoples R China
[3] Zhejiang Pharmaceut Coll, Fac Food Sci, Ningbo, Peoples R China
关键词
dietary obesity; gut microbiota; novel high-DHA tuna oil; ADIPOSE-TISSUE; MEDIATORS; WEIGHT;
D O I
10.1002/fsn3.1941
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Studies have documented the benefits of fish oil in different diseases because of its high n-3 polyunsaturated fatty acid content. However, these studies mostly used commercially available fish oil supplements with a ratio of 18/12 for eicosapentaenoic acid and docosahexaenoic acid (DHA). However, increasing DHA content for this commonly used ratio might bring out a varied metabolic effect, which have remained unclear. Thus, in this study, a novel tuna oil (TO) was applied to investigate the effect of high-DHA content on the alteration of the gut microbiota and obesity in high-fat diet mice. The results suggest that high-DHA TO (HDTO) supplementation notably ameliorates obesity and related lipid parameters and restores the expression of lipid metabolism-related genes. The benefits of TOs were derived from their modification of the gut microbiota composition and structure in mice. A high-fat diet triggered an increased Firmicutes/Bacteroidetes ratio that was remarkably restored by TOs. The number of obesity-promoting bacteria-Desulfovibrio, Paraeggerthella,Terrisporobacter, Millionella, Lachnoclostridium, Anaerobacterium, and Ruminiclostridium-was dramatically reduced. Desulfovibrio desulfuricans, Alistipes putredinis, and Millionella massiliensis, three dysbiosis-related species, were especially regulated by HDTO. Regarding the prevention of obesity, HDTO outperforms the normal TO. Intriguingly, HDTO feeding to HFD-fed mice might alter the arginine and proline metabolism of intestinal microbiota.
引用
收藏
页码:6513 / 6527
页数:15
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