Adjuvant therapy in high risk prostate cancer: The argument PRO

被引：2

作者：

Hammerer, P ^{[1
]}

机构：

[1] Stadt Klinikum Braunschweig, Urol Klin, D-38126 Braunschweig, Germany

来源：

EUROPEAN UROLOGY SUPPLEMENTS | 2004年 / 3卷 / 03期

关键词：

prostate cancer; hormones; treatment; prognosis;

D O I：

10.1016/j.eursup.2004.02.007

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Most patients diagnosed with localized prostate cancer today are cured with surgery or radiation therapy to the prostate. However, a subset of patients can be defined as having a high risk of failure with standard treatment. This risk stratification for disease recurrence is based on established parameters for T stage, Gleason score and PSA. Adjuvant therapy after surgery has been applied in other tumors and may improve local control, progression-free survival and survival. In men with extracapsular disease or positive surgical margins after radical prostatectomy, adjuvant radiotherapy is a common treatment option. Placebo controlled randomized studies on adjuvant hormonal therapy have resulted in improved progression-free survival and prolonged survival. Drug toxicity and the impact of treatment on quality of life are important considerations when selecting an adjuvant therapy. (C) 2004 Published by Elsevier B.V.

引用

页码：39 / 42

页数：4

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