Microscale Chiral HPLC in Support of Pharmaceutical Process Research

被引：42
作者：
Welch, Christopher J. [1 ]
机构：
[1] Merck & Co Inc, Separat & Purificat Ctr Excellence, Rahway, NJ 07065 USA
来源：
CHIRALITY | 2009年 / 21卷 / 01期
关键词：
chiral; HPLC; microcolumn; capillary; chip; microfluidic; LIQUID-CHROMATOGRAPHY; STATIONARY-PHASE; RAPID EVALUATION; ENANTIOSEPARATIONS; DERIVATIVES; TOOL; MS;
D O I：
10.1002/chir.20625
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some recent developments in the use of microscale chiral HPLC for supporting pharmaceutical process research are reviewed, including multiparallel high throughput analysis to support high throughput experimentation studies, rapid multiparallel chromatographic method development, and on-line reaction monitoring. Green chemistry advantages of the approach include greatly reduced solvent consumption, waste generation, and stationary phase requirement relative to conventional chiral HPLC. Chirality 21:114-118, 2009. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码：114 / 118
页数：5
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