Monocyte chemotactic protein-1 levels in the vitreons of patients with proliferative vitreoretinopathy

被引:29
作者
Mitamura, Y
Takeuchi, S
Yamamoto, S
Yamamoto, T
Tsukahara, I
Matsuda, A
Tagawa, Y
Mizue, Y
Nishihira, J
机构
[1] Sapporo Med Univ, Dept Ophthalmol, Sch Med, Chuo Ku, Sapporo, Hokkaido 0608543, Japan
[2] Toho Univ, Sakura Hosp, Dept Ophthalmol, Sakura, Chiba 2748510, Japan
[3] Hokkaido Univ, Sch Med, Dept Ophthalmol, Sapporo, Hokkaido 060, Japan
[4] Hokkaido Univ, Sch Med, Cent Res Inst, Sapporo, Hokkaido 060, Japan
[5] Sapporo Immunodiag Lab, Sapporo, Hokkaido, Japan
关键词
macrophage migration inhibitory factor; monocyte chemotactic protein-1; proliferative vitreoretinopathy; vitreous;
D O I
10.1016/S0021-5155(01)00497-X
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To assess the potential role of monocyte chemotactic protein-1 (MCP-1) in the pathogenesis of proliferative vitreoretinopathy (PVR) and to investigate its possible interaction with the macrophage migration inhibitory factor (MIF). Methods: We assayed MCP-1 and MIF levels in the vitreous samples of 85 consecutive patients with PVR (29 eyes), rhegmatogenous retinal detachment (RRD, 22 eyes), and macular hole or idiopathic epimacular membrane (controls; 34 eyes), by enzyme-linked immunosorbent assay. Results: Vitreous levels of MCP-1 were 1760.7 +/- 471.3 pg/mL (mean +/- SD) in PVR patients, 1200.4 +/- 579.8 pg/mL in RRD patients, and 436.3 +/- 286.1 pg/mL in the controls. Vitreous MCP-1 levels in PVR patients were significantly higher than those in RRD patients and in the controls (P < .0001, respectively). MCP-1 levels in grade C of PVR (1883.7 +/- 479.5 pg/mL) were significantly greater than those in grade D (1437.8 +/- 258.8 pg/mL) (P = .0112). Vitreous concentrations of MCP-1 had no correlation with those of MIF. Conclusions: The results indicate the possibility that MCP-1 may have a role mainly in the early stage of PVR and that the role of MCP-1 in PVR may differ from that of MIF. (C) 2002 Japanese Opthalmological Society.
引用
收藏
页码:218 / 221
页数:4
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