Nicotinic acetylcholine receptors in neuropathic and inflammatory pain

被引：101

作者：

Hone, Arik J. ^{[1
]}

McIntosh, J. Michael ^{[1
,2
,3
]}

机构：

[1] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Psychiat, Salt Lake City, UT USA

[3] George E Whalen Vet Affairs Med Ctr, Salt Lake City, UT USA

来源：

FEBS LETTERS | 2018年 / 592卷 / 07期

关键词：

alpha-conotoxin RgIA; cancer pain; inflammatory pain; neuropathic pain; nicotinic acetylcholine receptors; POSITIVE ALLOSTERIC MODULATOR; CHOLINERGIC ANTIINFLAMMATORY PATHWAY; ROOT GANGLION NEURONS; ALPHA-O-CONOTOXIN; GABAERGIC SYNAPTIC-TRANSMISSION; SUPERIOR CERVICAL-GANGLION; NITRIC-OXIDE SYNTHASE; AGONIST BINDING-SITE; VAGUS NERVE; SPINAL-CORD;

D O I：

10.1002/1873-3468.12884

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic targets for the treatment of pain and inflammation, but despite more than 30 years of research, there are currently no FDA-approved analgesics that are specific for these receptors. Much of the initial research effort focused on the alpha 4 beta 2 nAChR subtype, but more recently, additional subtypes have been identified as promising new leads and include alpha 6 beta 4, alpha 7, and alpha 9-containing nAChRs. This Review will focus on the distribution of these nAChRs in the cell types involved in neuropathic pain and inflammation and the activity of currently available nicotinic ligands.

引用

页码：1045 / 1062

页数：18

共 185 条

[11] The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain [J].