Recruitment of γδ T lymphocytes to tumors A new role for the pleiotropic chemokine CCL2

被引：5

作者：

Lanca, Telma ^{[1
,2
]}

Silva-Santos, Bruno ^{[1
,3
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Mol Med, P-1699 Lisbon, Portugal

[2] Netherlands Canc Inst, Amsterdam, Netherlands

[3] Inst Gulbenkian Ciencias, Oeiras, Portugal

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 08期

关键词：

CCL2; CCR2; chemokines; gamma delta T cells; tumor-infiltrating lymphocytes; SUPPRESSOR-CELLS; MICROENVIRONMENT; INFILTRATION; METASTASIS; PATHWAY;

D O I：

10.4161/onci.25461

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the promise of targeting gamma delta T cells for cancer immunotherapy, the mechanisms underpinning the recruitment of this T-cell subsets to neoplastic lesions remain poorly understood. we have recently identified the pro-inflammatory chemokine CCL2 and its receptor CCR2 as key molecular determinants of gamma delta T-cell migration and tumor infiltration.

引用

页数：3

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