Chiral-at-Metal Octahedral Iridium Catalyst for the Asymmetric Construction of an All-Carbon Quaternary Stereocenter

被引：106

作者：

Chen, Liang-An ^{[1
,2
]}

Tang, Xiaojuan ^{[1
,2
]}

Xi, Jianwei ^{[1
,2
]}

Xu, Weici ^{[1
,2
]}

Gong, Lei ^{[1
,2
]}

Meggers, Eric ^{[1
,2
,3
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Biol Chem, Xiamen 361005, Peoples R China

[3] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 52期

关键词：

asymmetric catalysis; chirality; hydrogen bonds; iridium; quaternary stereocenter; FRIEDEL-CRAFTS ALKYLATION; ENANTIOSELECTIVE CONSTRUCTION; STEREOGENIC CENTERS; CONJUGATE ADDITION; BOND DONORS; COMPLEXES; ORGANOCATALYSIS; HYDROGENATION; NITROALKENES; POTASSIUM;

D O I：

10.1002/anie.201306997

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metal-templated organocatalysis: The enantioselective formation of an all-carbon quaternary stereocenter is catalyzed by the ligand sphere of an inert bis-cyclometalated iridium complex (see picture). In this complex, the metal-centered chirality serves as the sole source for the effective asymmetric induction. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：14021 / 14025

页数：5

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