Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors

被引：60
作者：
Arima, Hidetoshi [1 ]
Motoyama, Keiichi [1 ]
Higashi, Taishi [1 ]
机构：
[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Kumamoto 8620973, Japan
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2013年 / 65卷 / 09期
基金：
日本学术振兴会;
关键词：
Cyclodextrin; Glucronylglucosyl-beta-cyclodextrin; Polyamidoamine dendrimer; Gene delivery; DNA; polypseudorotaxane; TARGETED GENE DELIVERY; CARBOHYDRATE-CONTAINING POLYCATIONS; BETA-CYCLODEXTRIN; POTENTIAL USE; ALPHA-CYCLODEXTRINS; IN-VITRO; FUNCTIONALIZED DENDRIMERS; GLYCOPEPTIDE DENDRIMERS; HEPATOMA-CELLS; DNA;
D O I：
10.1016/j.addr.2013.04.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The widespread use of various cyclodextrin (CyD)-appended polymers and polyrotaxanes as gene carriers has been reported. Among the various polyamidoamine dendrimer (dendrimer) conjugates with CyDs (CDE), the dendrimer (G3) conjugate with alpha-CyD having an average degree of substitution (DS) of 2.4 (alpha-CDE (G3, DS 2)) displayed remarkable properties as DNA carriers. In an attempt to develop cell-specific gene transfer carriers, we prepared some sugar-appended alpha-CDEs, e.g. mannosylated, galactosylated, and lactosylated alpha-CDEs. In addition, PEGylated Lac-alpha-CDEs (G3) were prepared and evaluated as a hepatocyte-selective and serum-resistant gene transfer carrier. Moreover, PEGylated-alpha-CDE/CyD polypseudorotaxane systems for novel sustained DNA release system have been developed. Interestingly, glucronylglucosyl-beta-cyclodextrin (GUG-beta-CyD) conjugates with dendrimer (G2) (GUG-beta-CDE (G2)) had superior gene transfer activity to alpha-CDE (G2), expecting a development of new series of sugar-appended CDEs over alpha-CDEs (G2). Collectively, sugar-appended alpha-CDEs have the potential as novel cell-specific and safe carriers for DNA. (C) 2013 Elsevier B.V. All rights reserved.
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页码：1204 / 1214
页数：11
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