Genetic diversity of Anaplasma marginale strains from an outbreak of bovine anaplasmosis in an endemic area

被引：36
作者：
Alamzan, Consuelo [1 ]
Medrano, Citlaly [1 ]
Ortiz, Martin
de la Fuente, Jose [2 ,3 ]
机构：
[1] Univ Autonoma Tamaulipas, Fac Med Vet & Zootecnia, Victoria 87000, Tamaulipas, Mexico
[2] Oklahoma State Univ, Dept Vet Pathobiol, Ctr Vet Hlth Sci, Stillwater, OK 74078 USA
[3] CSIC UCLM JCCM, IREC, Inst Invest Recursos Cineget, Ciudad Real 13005, Spain
来源：
VETERINARY PARASITOLOGY | 2008年 / 158卷 / 1-2期
关键词：
Anaplasmosis; Major surface protein; Evolution; Tick; Genetics; Mexico; Boophilus microplus;
D O I：
10.1016/j.vetpar.2008.08.015
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Anaplasma marginate is a tick-borne pathogen of cattle that causes the disease bovine anaplasmosis worldwide. Major surface proteins (MSPs) are involved in host-pathogen and tick-pathogen interactions and have been used as markers for the genetic characterization of A. marginate strains. A. marginate genotypes are highly variable in endemic areas worldwide. The genetic composition of A. marginate strains during anaplasmosis outbreaks has been characterized in one study only which reported a single msp1 alpha genotype in infected cattle. However, more information is required to characterize whether a single genotype is responsible for an anaplasmosis outbreak or whether multiple genotypes can cause disease in naive cattle within a single herd in endemic areas. The aim of this study was to characterize the genetic diversity of A. marginate strains from an outbreak of bovine anaplasmosis in the State of Tamaulipas, Mexico. A. marginate genotypes were characterized at the molecular level using msp4 and msp1 alpha gene sequences. The results revealed that several A. marginate genotypes are present in cattle during acute anaplasmosis outbreaks, thus suggesting that mechanical transmission or stochastic biological transmission through equally efficient independent transmission events may explain A. marginate genotype frequency in a cattle herd during acute bovine anaplasmosis outbreaks in endemic areas. The results reported herein corroborated the genetic heterogeneity of A. marginate strains in endemic regions worldwide. The development and implementation of anaplasmosis control measures is dependent upon understanding the epidemiology of A. marginate in endemic regions, including the characterization of the genetic diversity of strains that produce outbreaks of bovine anaplasmosis. (C) 2008 Elsevier B.V. All rights reserved.
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页码：103 / 109
页数：7
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