Effect of lidocaine administration on the enkephalin-degrading aminopeptidase activities in discrete areas of the rat brain

被引：2

作者：

deGandarias, JM ^{[1
]}

Irazusta, J ^{[1
]}

Fernandez, D ^{[1
]}

Varona, A ^{[1
]}

Gil, J ^{[1
]}

Casis, L ^{[1
]}

机构：

[1] UNIV BASQUE COUNTRY,SCH MED,DEPT PHYSIOL,BILBAO,SPAIN

来源：

GENERAL PHARMACOLOGY | 1997年 / 29卷 / 03期

关键词：

lidocaine; aminopeptidase activity; aminopeptidase M; enkephalin; rat brain;

D O I：

10.1016/S0306-3623(96)00477-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The levels of three aminopeptidase activities involved in the degradation of enkephalins (soluble, M and MII) in several rat brain areas were studied after lidocaine administration. 2. Soluble aminopeptidase activity showed decreases in the frontal cortex and in the pituitary gland after treatment. 3. No significant changes in the complete membrane-bound aminopeptidase activity were appreciated in any other of the brain areas. 4. However, decreases of the membrane-bound puromycin-insensitive aminopeptidase activity in the frontal cortex, the hippocampus and the thalamus, after lidocaine administration, were observed. (C) 1997 Elsevier Science Inc.

引用

页码：489 / 493

页数：5

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