A novel hemispherical spectro-polarimetric scattering instrument for skin lesion imaging

被引:11
作者
Boulbry, Bruno [1 ]
Germer, Thomas A. [1 ]
Ramella-Roman, Jessica C. [1 ,2 ]
机构
[1] Natl Inst Stand & Technol, Opt Technol Div, Gaithersburg, MD 20899 USA
[2] Catholic Univ Amer, Dept Biomed Engn, Washington, DC 20064 USA
来源
PHOTONIC THERAPEUTICS AND DIAGNOSTICS II | 2006年 / 6078卷
关键词
imaging; polarization; skin cancer; spectroscopy;
D O I
10.1117/12.648164
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
We present a novel spectro-polarimetric instrument based on hemispherical backscattering for the assessment of superficial skin lesions. The system is capable of capturing polarized light images non-invasively. The effect of the rough skin backscattering is eliminated with the use of out-of-plane illumination. A glass slide with an index matching fluid, commonly used in polarized light imaging, is no longer necessary. The system is composed of sixteen polarized light sources that provide red, green, or blue illumination. The light sources are distributed on a hemispherical shell, and each source produces a collimated beam incident on the center of the hemisphere. A Stokes vector imaging system is mounted on the shell at an oblique angle to the sample normal and consists of a 12-bit scientific camera, two liquid crystal variable retarders, and a fixed polarizer. Stokes vector images of light scattered towards the camera direction are generated for each source. A useful decomposition of the Stokes vector is presented. Examples of images generated by the system are presented.
引用
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页数:7
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