Relationship between subclinical atherosclerosis, blood pressure, and lipid profile in obese children and adolescents: a systematic review

The present study aimed to systematically review the literature about intima-media thickness (IMT), blood pressure (BP), and lipid profile (LP) in obese and non-obese children and adolescents. The search was carried out in electronic databases (PubMed, Bireme, and Elsevier ScienceDirect) between 2000-2010. The following keywords, in English, were used: "obesity", "adolescents", "atherosclerosis" and "child", using two combinations: obesity+child+atherosclerosis and obesity+adolescents+atherosclerosis. The electronic search resulted in 3,211 manuscripts. After analysis of the inclusion criteria, 13 papers were selected. Of these, two studies showed significant correlation between IMT and the variables BP, LDL, and triglycerides. In other studies, no significant correlations were found. There is a wide methodological variability across the studies. However, obese children and adolescents had higher values of IMT, BP, and LP. Arq Bras Endocrinol Metab. 2013;57(1):1-6