Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

被引：83

作者：

Huang, Guan-Jhong ^{[1
]}

Deng, Jeng-Shyan ^{[2
]}

Huang, Shyh-Shyun ^{[3
]}

Lee, Chao-Ying ^{[2
]}

Hou, Wen-Chi ^{[4
]}

Wang, Sheng-Yang ^{[5
]}

Sung, Ping-Jyun ^{[6
,7
]}

Kuo, Yueh-Hsiung ^{[8
]}

机构：

[1] China Med Univ, Coll Pharm, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan

[2] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413, Taiwan

[3] China Med Univ, Coll Pharm, Sch Pharm, Taichung 404, Taiwan

[4] Taipei Med Univ, Grad Inst Pharmacognosy, Taipei, Taiwan

[5] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan

[6] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[7] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[8] China Med Univ, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan

来源：

FOOD CHEMISTRY | 2013年 / 141卷 / 03期

关键词：

Antrodia camphorata; Eburicoic acid; Dehydroeburicoic acid; Anti-inflammation; NO; TNF-alpha; TETRACHLORIDE-INDUCED HEPATOTOXICITY; IN-VITRO; ANTI-INFLAMMATION; FRUITING BODY; MECHANISM; SILYMARIN; DAMAGE;

D O I：

10.1016/j.foodchem.2013.03.061

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The hepatoprotective effects of eburicoic acid (TR1) and dehydroeburicoic acid (TR2) from Antrodia camphorata (AC) against carbon tetrachloride (CCl4)-induced liver damage were investigated in mice. TR1 and TR2 was administered intraperitoneally (i.p.) for 7 days prior to the administration of CCl4. Pretreatment with TR1 and TR2 prevented the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and liver lipid peroxides in CCl4-treated mice. The activities of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)], nitric oxide (NO) production, and tumour necrosis factor-alpha (TNF-alpha) were decreased after the treatment with TR1 and TR2 in CCl4-treated mice. Western blotting revealed that TR1 and TR2 significantly decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions and increased the expression of cytochrome P4502E1 (CYP2E1) in CCl4-treated mice. Therefore, we speculate that TR1 and TR2 protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3020 / 3027

页数：8

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