Advanced nasopharyngeal carcinoma and radiation-induced meningioma in dizygotic twins - A rare case report

The case of a dizygotic twin diagnosed with advanced nasopharyngeal carcinoma (NPC) and radiation induced meningioma is reviewed. The main treatment approach was high-dose radiotherapy to the involved and presumably involved areas of disease. Radiation therapy alone can achieve local control and survival rates of 70 to 80%, depending mainly on the initial stage. Serious long-term side effects of wide-field radiation therapy in NPC are rare but may include temporal lobe necrosis, primary and/or secondary panhypopituitarism and cranial nerve palsies.