Association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with sepsis and acute kidney dysfunction

被引：55

作者：

Martensson, Johan ^{[1
]}

Bell, Max ^{[1
]}

Xu, Shengyuan ^{[2
]}

Bottai, Matteo ^{[3
]}

Ravn, Bo ^{[1
]}

Venge, Per ^{[2
]}

Martling, Claes-Roland ^{[1
]}

机构：

[1] Karolinska Inst, Sect Anaesthesia & Intens Care Med, Dept Physiol & Pharmacol, Stockholm, Sweden

[2] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[3] Karolinska Inst, Inst Environm Med, Unit Biostat, S-10401 Stockholm, Sweden

来源：

BIOMARKERS | 2013年 / 18卷 / 04期

关键词：

Acute kidney injury; biomarkers; critical care; CRP; inflammation; PCT; CRITICALLY-ILL PATIENTS; ELIMINATION RATE; IN-VIVO; PROCALCITONIN; INJURY; HNL; URINE; DEFINITIONS; EXPRESSION; SECRETION;

D O I：

10.3109/1354750X.2013.787460

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by injured kidney cells as well as by activated neutrophils in response to bacterial infections. We assessed the influence of acute renal dysfunction on the association between plasma NGAL and sepsis. Methods: NGAL was measured daily in 138 critically ill patients. Simultaneous recordings of sepsis status and fluctuations in renal function were made. Results: Elevated NGAL was associated with sepsis independent of level of acute renal dysfunction. A cut-off value of 98 ng/mL distinguished sepsis from systemic inflammation with high sensitivity (0.77) and specificity (0.79). Conclusions: Plasma NGAL can help clinicians to identify bacterial infections in critically ill patients.

引用

页码：349 / 356

页数：8

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