Peripheral Arterial Stiffness in Primary Aldosteronism

被引:26
作者
Rosa, J. [1 ,2 ]
Somloova, Z. [1 ]
Petrak, O. [1 ]
Strauch, B. [1 ]
Indra, T. [1 ]
Senitko, M. [3 ]
Zelinka, T. [1 ]
Holaj, R. [1 ]
Widimsky, J., Jr. [1 ]
机构
[1] Charles Univ Prague, Gen Fac Hosp, Dept Internal Med 3, Fac Med 1, U Nemocnice 2, Prague 12808, Czech Republic
[2] Charles Univ Prague, Univ Hosp Kralovske Vinohrady, Dept Internal Med 3, Fac Med 3, Prague 12808, Czech Republic
[3] Univ Mississippi, Med Ctr, Dept Med, University, MS 38677 USA
关键词
Peripheral arterial stiffness; Primary aldosteronism; Peripheral pulse wave velocity; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR EVENTS; CAROTID-ARTERY; HYPERTENSION; SODIUM; ASSOCIATION; PREVALENCE;
D O I
10.33549/physiolres.932344
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Aldosterone overproduction increases arterial wall stiffness by accumulation of different types of collagen fibres and growth factors. Our previous studies showed that central (aortic) arterial stiffness is increased in primary aldosteronism (PA) independently of concomitant hypertension and that these changes might be reversible after successful adrenalectomy. There is limited data available on the potential impact of mineralocorticoid overproduction on the deterioration of peripheral arterial stiffness. The current study was thus aimed at investigating the effect of aldosterone overproduction on peripheral arterial stiffness assessed by peripheral (femoral-ankle) pulse wave velocity (PWV) in PA patients compared with essential hypertension (EH) patients. Forty-nine patients with confirmed PA and 49 patients with EH were matched for age, blood pressure, body mass index, lipid profile, and fasting glucose. PWV was obtained using the Sphygmocor applanation tonometer. Both peripheral and central PWV were significantly higher in PA patients compared to EH patients, while clinical blood pressures were similar. Plasma aldosterone level was the main predictor of peripheral PWV in PA. Our data indicate aldosterone overproduction in PA does not preferentially affect central arterial system. Fibroproliferative effect of higher aldosterone levels lead to alteration of central-elastic as well as peripheral-muscular arteries with subsequent increase in its stiffness.
引用
收藏
页码:461 / 468
页数:8
相关论文
共 28 条
[1]   Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism [J].
Bernini, Giampaolo ;
Galetta, Fabio ;
Franzoni, Ferdinando ;
Bardini, Michele ;
Taurino, Chiara ;
Bernardini, Melania ;
Ghiadoni, Lorenzo ;
Bernini, Matteo ;
Santoro, Gino ;
Salvetti, Antonio .
JOURNAL OF HYPERTENSION, 2008, 26 (12) :2399-2405
[2]   Cardiovascular outcomes in patients with primary aldosteronism after treatment [J].
Catena, Cristiana ;
Colussi, GianLuca ;
Nadalini, Elisa ;
Chiuch, Alessandra ;
Baroselli, Sara ;
Lapenna, Roberta ;
Sechi, Leonardo A. .
ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (01) :80-85
[3]   Differing effects of aging on central and peripheral blood pressures and pulse wave velocity: a direct intraarterial study [J].
Choi, Cheol Ung ;
Kim, Eung Ju ;
Kim, Seong Hwan ;
Shin, Seung Yong ;
Choi, Un-Jung ;
Kim, Jin Won ;
Lim, Hong Euy ;
Rha, Seung-Woon ;
Park, Chang Gyu ;
Seo, Hong Seog ;
Oh, Dong Joo .
JOURNAL OF HYPERTENSION, 2010, 28 (06) :1252-1260
[4]   Case detection, diagnosis, and treatment of patients with primary aldosteronism: An endocrine society clinical practice guideline [J].
Funder, John W. ;
Carey, Robert M. ;
Fardella, Carlos ;
Gomez-Sanchez, Celso E. ;
Mantero, Franco ;
Stowasser, Michael ;
Young, William F., Jr. ;
Montori, Victor M. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (09) :3266-3281
[5]   Increased intima-media thickness of the common carotid artery in primary aldosteronism in comparison with essential hypertension [J].
Holaj, Robert ;
Zelinka, Tomas ;
Wichterle, Dan ;
Petrak, Ondrej ;
Strauch, Branislav ;
Widimsky, Jiri, Jr. .
JOURNAL OF HYPERTENSION, 2007, 25 (07) :1451-1457
[6]   Effect of aldosterone and mineralocorticoid receptor blockade on vascular inflammation [J].
Joffe, HV ;
Adler, GK .
HEART FAILURE REVIEWS, 2005, 10 (01) :31-37
[7]   The Association Between Ankle Brachial Pressure Index and Pulse Wave Velocity: Clinical Implication of Pulse Wave Velocity [J].
Khandanpour, Nader ;
Armon, Matthew P. ;
Jennings, Barbara ;
Clark, Allan ;
Meyer, Felicity J. .
ANGIOLOGY, 2009, 60 (06) :732-738
[8]   Aldosterone-to-renin ratio, arterial stiffness, and the response to aldosterone antagonism in essential hypertension [J].
Mahmud, A ;
Feely, J .
AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (01) :50-55
[9]   2007 ESH-ESC practice guidelines for the management of arterial hypertension - ESH-ESC task force on the management of arterial hypertension [J].
Mancia, Giuseppe ;
De Backer, Guy ;
Dominiczak, Anna ;
Cifkova, Renata ;
Fagarde, Robert ;
Germanof, Giuseppe ;
Grassi, Guido ;
Heagertyh, Anthony M. ;
Kjeldsen, Sverre E. ;
Laurenti, Stephanie ;
Narkiewicz, Krzysztof ;
Ruilopel, Luis ;
Rynkiewicz, Andrzej ;
Schmiedern, Roland E. ;
Boudiero, Harry A. J. Struijker ;
Zanchetti, Alberto .
JOURNAL OF HYPERTENSION, 2007, 25 (09) :1751-1762
[10]   Structural, Functional, and Molecular Alterations Produced by Aldosterone Plus Salt in Rat Heart: Association With Enhanced Serum and Glucocorticoid-regulated Kinase-1 Expression [J].
Martin-Fernandez, Beatriz ;
de las Heras, Natalia ;
Miana, Maria ;
Ballesteros, Sandra ;
Delgado, Carmen ;
Song, Su ;
Hintze, Thomas ;
Cachofeiro, Victoria ;
Lahera, Vicente .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2011, 57 (01) :114-121