Synthesis of [1,2,3]-triazolo[1,5-a][1,4]benzodiazepines via an unprecedented one-pot Cu-catalyzed azidation-cyclization reaction

被引：27

作者：

Hooyberghs, Geert ^{[1
]}

De Coster, Hendrik ^{[1
]}

Vachhani, Dipak D. ^{[1
]}

Ermolat'ev, Denis S. ^{[1
]}

Van der Eycken, Erik V. ^{[1
]}

机构：

[1] Univ Leuven KU Leuven, Dept Chem, LOMAC, B-3001 Louvain, Belgium

来源：

TETRAHEDRON | 2013年 / 69卷 / 21期

关键词：

Medium-sized ring; Benzodiazepine; Tandem reaction; PRIVILEGED STRUCTURES; DISCOVERY;

D O I：

10.1016/j.tet.2013.03.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel three-step approach leading to [1,2,3]-triazolo[1,5-a][1,4]benzodiazepines in moderate to good yields has been developed. The key step is an unprecedented one-pot Cu-catalyzed azidation-cyclization reaction of ortho-bromobenzylpropargylamines. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：4331 / 4337

页数：7

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