p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis

被引：5

作者：

Alaizari, Nader Ahmed ^{[1
,2
]}

Tarakji, Bassel ^{[1
]}

Al-Maweri, Sadeq Ali ^{[1
,2
]}

Al-Shamiri, Hashem Motahir ^{[1
]}

Darwish, Shourouk ^{[1
]}

Baba, Feras ^{[3
]}

机构：

[1] Al Farabi Coll Dent & Nursing, Dept Oral & Maxillofacial Sci, Riyadh, Saudi Arabia

[2] Sanaa Univ, Fac Dent, Dept Oral Med & Pathol, Sanaa, Yemen

[3] Aleppo Univ, Fac Dent, Aleppo, Syria

来源：

ARCHIVES OF ORAL BIOLOGY | 2015年 / 60卷 / 09期

关键词：

p53; Immunohistochemical; Systemic review; Meta-analysis; Pleomorphic adenoma; IMMUNOHISTOCHEMICAL FEATURES; BENIGN; TUMORS; MUTATIONS; RECEPTOR; MARKERS; BCL-2; KI-67; PCNA; BIAS;

D O I：

10.1016/j.archoralbio.2015.06.019

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective: There are conflicting data regarding immunohistochemical expression of p53 in pleomorphic adenoma. This systematic review and meta-analysis aimed to examine whether p53 expression has a role in the pathogenesis of pleomorphic adenoma. Design: A comprehensive literature search for relevant studies published from 2000 up to end of 2014 was performed using PubMed, EMBASE and the Cochrane Library Databases. Only articles in which p53 detected by immunohistochemical staining were included. The meta-analysis was done using Comprehensive Meta-Analysis software. Results: Eighteen eligible studies were included in this meta-analysis. Heterogeneity measures showed a statistically significant Cochrane Q value (P-value < 0.001). The random effects model showed an effect size of 0.254 with a 95% CI (0.139-0.417). The overall p53 positivity is 25.4%. Conclusion: Mutant p53 has to be detected by more precise techniques to emphasize on its role in development of pleomorphic adenoma of salivary gland. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1437 / 1441

页数：5

共 35 条

[21] P53 and Ki-67 antigen expression in small oral biopsy specimens of salivary gland tumors [J].

Lazzaro, B ;

Cleveland, D .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 2000, 89 (05) :613-617

[22] THE P53 TUMOR SUPPRESSOR GENE [J].

LEVINE, AJ ;

MOMAND, J ;

FINLAY, CA .

NATURE, 1991, 351 (6326) :453-456

[23] Prognostic role of apoptotic, Bcl-2, c-erbB-2 and p53 tumor markers in salivary gland malignancies [J].

Nagler, RM ;

Kerner, H ;

Ben-Eliezer, S ;

Minkov, I ;

Ben-Itzhak, O .

ONCOLOGY, 2003, 64 (04) :389-398

[24]

Nordkvist A, 2000, INT J ONCOL, V16, P477

[25] Genetic analysis of DNA microsatellite loci in salivary gland tumours: comparison with immunohistochemical detection of hMSH2 and p53 proteins [J].

Ohki, K ;

Kumamoto, H ;

Ichinohasama, R ;

Suzuki, M ;

Yamaguchi, T ;

Echigo, S ;

Motegi, K ;

Ooya, K .

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2001, 30 (06) :538-544

[26] Precancerous foci in pleomorphic adenoma of the salivary gland:: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry [J].

Ohtaké, S ;

Cheng, J ;

Ida, H ;

Suzuki, M ;

Ohshiro, K ;

Zhang, WG ;

Saku, T .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2002, 31 (10) :590-597

[27] IMMUNOHISTOCHEMICAL LOCALIZATION OF ESTRADIOL, PROGESTERONE, AND PROGESTERONE-RECEPTOR IN HUMAN SALIVARY-GLANDS AND SALIVARY ADENOID CYSTIC CARCINOMAS [J].

OZONO, S ;

ONOZUKA, M ;

SATO, K ;

ITO, Y .

CELL STRUCTURE AND FUNCTION, 1992, 17 (03) :169-175

[28] Salivary gland tumors in children and adolescents: a clinicopathologic and immunohistochemical study of fifty-three cases [J].

Perez, DED ;

Pires, FR ;

Alves, FA ;

Almeida, OP ;

Kowalski, LP .

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 2004, 68 (07) :895-902

[29] Comparison of two methods to detect publication bias in meta-analysis [J].

Peters, JL ;

Sutton, AJ ;

Jones, DR ;

Abrams, KR ;

Rushton, L .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (06) :676-680

[30] Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography [J].

Sanderson, Simon ;

Tatt, Lain D. ;

Higgins, Julian P. T. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2007, 36 (03) :666-676

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