Protective Effect of Neferine Against Isoproterenol-Induced Cardiac Toxicity

被引：57

作者：

Lalitha, Gurusamy ^{[1
]}

Poornima, Paramasivan ^{[1
]}

Archanah, Arjunan ^{[1
]}

Padma, Viswanadha Vijaya ^{[1
]}

机构：

[1] Bharathiar Univ, Sch Biotechnol & Genet Engn, Dept Biotechnol, Anim Tissue Culture Lab, Coimbatore 641046, Tamil Nadu, India

来源：

CARDIOVASCULAR TOXICOLOGY | 2013年 / 13卷 / 02期

关键词：

Neferine; Isoproterenol; Marker enzymes; Oxidative stress; Lipid peroxidation; Myocardial infarction; INDUCED MYOCARDIAL-INFARCTION; NELUMBO-NUCIFERA GAERTN; LIPID-PEROXIDATION; OXIDATIVE STRESS; INDUCED NECROSIS; HEART; GLUTATHIONE; ACID; RATS; EMBRYO;

D O I：

10.1007/s12012-012-9196-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study was designed to investigate the cardioprotective effect of neferine against isoproterenol-induced myocardial infarction. Neferine was given orally for 30 days, and isoproterenol was injected subcutaneously for 2 days. Histopathological examination of heart tissue of isoproterenol-treated rats showed myocardial necrosis. Biochemical analysis of isoproterenol-treated rats showed significant increase in the serum marker enzymes-creatine kinase, lactate dehydrogenase, and aspartate transaminase and increased serum glycoprotein components with a concomitant decrease in the heart tissue homogenate when compared to control. Increased lipid peroxidation and decreased antioxidants reduced glutathione, superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase and altered lipid profile in serum and tissue was also recorded in the isoproterenol-treated rats, whereas the rats which received neferine pre-treatment followed by isoproterenol injection showed minimal histological changes, absence of inflammation, and a significant decrease in the serum marker enzymes and serum glycoprotein components with a concomitant increase in the heart tissue homogenate when compared to isoproterenol group. Neferine pre-treatment restored the altered biochemical parameters and lipid profile to near normal. The results of the present study showed that neferine exerts strong antioxidant property against isoproterenol-induced oxidative stress and can be used as a potent cardioprotective agent against isoproterenol-induced myocardial infarction.

引用

页码：168 / 179

页数：12

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