Physical and Mental Quality of Life in Chronic Pancreatitis A Case-Control Study From the North American Pancreatitis Study 2 Cohort

被引：82

作者：

Amann, Stephen T. ^{[1
]}

Yadav, Dhiraj ^{[2
]}

Barmada, M. Micheal ^{[3
]}

O'Connell, Michael ^{[2
]}

Kennard, Elizabeth D. ^{[2
]}

Anderson, Michelle ^{[4
]}

Baillie, John ^{[5
]}

Sherman, Stuart ^{[6
]}

Romagnuolo, Joseph ^{[7
]}

Hawes, Robert H. ^{[7
]}

AlKaade, Samer ^{[8
]}

Brand, Randall E. ^{[2
]}

Lewis, Michele D. ^{[9
]}

Gardner, Timothy B. ^{[10
]}

Gelrud, Andres ^{[2
]}

Money, Mary E. ^{[11
]}

Banks, Peter A. ^{[12
]}

Slivka, Adam ^{[2
]}

Whitcomb, David C. ^{[2
,3
]}

机构：

[1] N Mississippi Med Ctr, Tupelo, MS USA

[2] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA

[4] Univ Michigan, Div Gastroenterol, Ann Arbor, MI 48109 USA

[5] Duke Univ, Med Ctr, Div Gastroenterol, Durham, NC 27710 USA

[6] Indiana Univ, Med Ctr, Dept Med, Indianapolis, IN USA

[7] Med Univ S Carolina, Ctr Digest Dis, Charleston, SC 29425 USA

[8] St Louis Univ, Sch Med, Dept Internal Med, St Louis, MO USA

[9] Mayo Clin, Dept Med, Jacksonville, FL 32224 USA

[10] Dartmouth Hitchcock Med Ctr, Hanover, NH USA

[11] Washington Cty Hosp, Hagerstown, MD USA

[12] Brigham & Womens Hosp, Dept Internal Med, Boston, MD USA

来源：

PANCREAS | 2013年 / 42卷 / 02期

关键词：

chronic pancreatitis; quality of life; SF-12; prospective; FOLLOW-UP; DIAGNOSIS; RESECTION; OUTCOMES; SF-12; HEAD; PAIN;

D O I：

10.1097/MPA.0b013e31826532e7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: The objective of this study was to define the quality of life (QOL) in patients with chronic pancreatitis (CP). Methods: We studied 443 well-phenotyped CP subjects and 611 control subjects prospectively enrolled from 20 US centers between 2000 and 2006 in the North American Pancreatitis Study 2. Responses to the SF-12 questionnaire were used to calculate the mental (MCS) and physical component summary scores (PCS) with norm-based scoring (normal >= 50). Quality of life in CP subjects was compared with control subjects after controlling for demographic factors, drinking history, smoking, and medical conditions. Quality of life in CP was also compared with known scores for several chronic conditions. Results: Both PCS (38 [SD, 11.5] vs 52 [SD, 9.4]) and MCS (44 [SD, 11.5] vs 51 [SD, 9.2]) were significantly lower in CP compared with control subjects (P < 0.001). On multivariable analyses, compared with control subjects, a profound decrease in physical QOL (PCS 12.02 points lower) and a clinically significant decrease in mental QOL (MCS 4.24 points lower) was seen due to CP. Quality of life in CP was similar to (heart, kidney, liver, lung disease) or worse than (nonskin cancers, diabetes mellitus, hypertension, rheumatoid arthritis) other chronic conditions. Conclusions: The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions.

引用

页码：293 / 300

页数：8

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