[2] Univ Pompeu Fabra, Hosp Mar Res Inst IMIM, Barcelona, Spain
[3] Univ Pompeu Fabra, Immunol Unit, Barcelona, Spain
来源:
FRONTIERS IN IMMUNOLOGY
|
2012年
/
3卷
关键词:
gene polymotphism;
human NK cells;
inhibitory receptors;
KIR;
NK cell receptors;
transcription;
D O I:
10.3389/fimmu.2012.00289
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
A recently developed anti-KIR2DL5 (CD158f) antibody has demonstrated KIR2DL5 expression on the surface of NK and T lymphocytes, making it the last functional KIR identified in the human genome. KIR2DL5 belongs to an ancestral lineage of KIR with Ig-like domains of the D0-D2 type, of which KIR2DL4, an HLA-G receptor, is the only other human member. Despite KIR2DL4 and KIR2DL5 being encoded by genes with similar domain usage, several KIR2DL5 functions resemble more closely those of KIR recognizing classical HLA class I molecules surface-expressed KIR2DL5 inhibits NK cells through the SHP-2 phosphatase and displays a clonal distribution on NK and T lymphocytes. No activating homolog of KIR2DL5 has been described in any species. The genetics of KIR2DL5 is complicated by duplication of its gene in an ancestor of modern humans living 1.7 million years ago. Both KIR2DL5 paralogs have undergone allelic diversification; the centromeric gene is most often represented by alleles whose expression is silenced epigenetically through DNA methylation, thus providing a natural system to investigate the regulation of KIR transcription. The role of KIR2DL5 in immunity is not completely understood, in spite of different attempts to define its ligand. Here we revisit the most relevant characteristics of KIR2DL5, an NK-cell receptor possessing a unique combination of genetic, structural, and functional features.
机构:
Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Abi-Rached, Laurent
;
Kuhl, Heiner
论文数: 0引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Genet, Berlin, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Kuhl, Heiner
;
Roos, Christian
论文数: 0引用数: 0
h-index: 0
机构:
German Primate Ctr, Primate Genet Lab, Gottingen, Germany
German Primate Ctr, Gene Bank Primates, Gottingen, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Roos, Christian
;
ten Hallers, Boudewijn
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
ten Hallers, Boudewijn
;
Zhu, Baoli
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Zhu, Baoli
;
Carbone, Lucia
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Carbone, Lucia
;
de Jong, Pieter J.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
de Jong, Pieter J.
;
Mootnick, Alan R.
论文数: 0引用数: 0
h-index: 0
机构:
Gibbon Conservat Ctr, Santa Clarita, CA 91380 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Mootnick, Alan R.
;
Knaust, Florian
论文数: 0引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Genet, Berlin, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Knaust, Florian
;
Reinhardt, Richard
论文数: 0引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Genet, Berlin, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Reinhardt, Richard
;
Parham, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Parham, Peter
;
Walter, Lutz
论文数: 0引用数: 0
h-index: 0
机构:
German Primate Ctr, Primate Genet Lab, Gottingen, Germany
German Primate Ctr, Gene Bank Primates, Gottingen, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
机构:
Univ Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Du, Z.
;
Sharma, S. K.
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Med, New Delhi 110029, IndiaUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Sharma, S. K.
;
Spellman, S.
论文数: 0引用数: 0
h-index: 0
机构:
NMDP, Minneapolis, MN USAUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Spellman, S.
;
Reed, E. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Reed, E. F.
;
Rajalingam, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
机构:
Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Abi-Rached, Laurent
;
Kuhl, Heiner
论文数: 0引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Genet, Berlin, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Kuhl, Heiner
;
Roos, Christian
论文数: 0引用数: 0
h-index: 0
机构:
German Primate Ctr, Primate Genet Lab, Gottingen, Germany
German Primate Ctr, Gene Bank Primates, Gottingen, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Roos, Christian
;
ten Hallers, Boudewijn
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
ten Hallers, Boudewijn
;
Zhu, Baoli
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Zhu, Baoli
;
Carbone, Lucia
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Carbone, Lucia
;
de Jong, Pieter J.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
de Jong, Pieter J.
;
Mootnick, Alan R.
论文数: 0引用数: 0
h-index: 0
机构:
Gibbon Conservat Ctr, Santa Clarita, CA 91380 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Mootnick, Alan R.
;
Knaust, Florian
论文数: 0引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Genet, Berlin, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Knaust, Florian
;
Reinhardt, Richard
论文数: 0引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Genet, Berlin, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Reinhardt, Richard
;
Parham, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USAStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
Parham, Peter
;
Walter, Lutz
论文数: 0引用数: 0
h-index: 0
机构:
German Primate Ctr, Primate Genet Lab, Gottingen, Germany
German Primate Ctr, Gene Bank Primates, Gottingen, GermanyStanford Univ, Dept Biol Struct, Stanford, CA 94305 USA
机构:
Univ Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Du, Z.
;
Sharma, S. K.
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Med, New Delhi 110029, IndiaUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Sharma, S. K.
;
Spellman, S.
论文数: 0引用数: 0
h-index: 0
机构:
NMDP, Minneapolis, MN USAUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Spellman, S.
;
Reed, E. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
Reed, E. F.
;
Rajalingam, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, UCLA Immunogenet Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA