How does sibutramine work?

被引：44
|
作者：
Lean, MEJ [1 ]
机构：
[1] Univ Glasgow, Dept Human Nutr, Royal Infirm, Glasgow G31 2ER, Lanark, Scotland
来源：
INTERNATIONAL JOURNAL OF OBESITY | 2001年 / 25卷 / Suppl 4期
关键词：
sibutramine; serotonin and noradrenaline reuptake inhibitor (SNRI); energy intake; energy expenditure; weight loss;
D O I：
10.1038/sj.ijo.0801931
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects-a reduction in energy intake and an increase in energy expenditure, which combine to promote and maintain weight loss.
引用
收藏
页码：S8 / S11
页数：4
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